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2-溴苯酚

2-溴苯酚用途

用于有机合成

2-溴苯酚名称

[ CAS 号 ]:
95-56-7

[ 中文名 ]:
邻溴苯酚

[ 英文名 ]:
2-Bromophenol

[中文别名 ]:

[英文别名 ]:

2-BROMOPHENOL (OH=1)
ORTHO-BROMOPHENOL
O-BROMOPHENOL
Phenol, 2-bromo-
2-Bromo phenethylamin
2-bromo-phenethylamine
BROMOPHENOL, 2-
EINECS 202-432-7
Bromophenol
2-(2-bromophenyl)ethan-amine

2-溴苯酚物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
194.5±0.0 °C at 760 mmHg

[ 熔点 ]:
5 °C

[ 分子式 ]:
C₆H₅BrO

[ 分子量 ]:
173.007

[ 闪点 ]:
42.2±0.0 °C

[ 精确质量 ]:
171.952377

[ PSA ]:
20.23000

[ LogP ]:
2.47

[ 外观性状 ]:
透明无色至略黄色液体

[ 蒸汽压 ]:
0.3±0.3 mmHg at 25°C

[ 折射率 ]:
1.605

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

[ 水溶解性 ]:
soluble

2-溴苯酚MSDS

2-溴苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ7875000

CHEMICAL NAME :: Phenol, o-bromo-

CAS REGISTRY NUMBER :: 95-56-7

BEILSTEIN REFERENCE NO. :: 1905115

LAST UPDATED :: 199709

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H5-Br-O

MOLECULAR WEIGHT :: 173.02

WISWESSER LINE NOTATION :: QR BE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 652 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 44(12),19,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 633 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 44(12),19,1979

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness

REFERENCE :: RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881- Volume(issue)/page/year: 16,449,1896

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(10),25,1988

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(10),25,1988 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993

2-溴苯酚安全信息

[ 符号 ]:

GHS02, GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226-H302-H315-H319-H335-H400

[ 警示性声明 ]:
P261-P273-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R10;R22;R36/37/38

[ 安全声明 (欧洲) ]:
S16-S36/37/39-S37/39-S26

[ 危险品运输编码 ]:
UN 1993 3/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
SJ7875000

[ 包装等级 ]:
III

[ 危险类别 ]:
3.2

[ 海关编码 ]:
29081000

2-溴苯酚合成路线

2-溴苯酚上下游产品

2-溴苯酚上游产品

2-溴苯酚下游产品

2-溴苯酚制备

由邻氨基酚经重氮化、溴代而得: (1)重氮化邻氨基酚与水搅拌均匀,加浓硫酸及碎冰降温至5℃以下。慢慢加亚硝酸钠溶液,反应温度保持5℃以下得重氮盐。(2)溴代将溴化亚铜加入氢溴酸溶解后,搅拌下加重氮盐,加完搅拌0.5h,放置,水蒸气蒸馏至馏出物无油状物为止,静置分出油层,将油状物进行减压分馏而得。

2-溴苯酚海关

[ 海关编码 ]: 2908199090

[ 中文概述 ]:
HS:2908199090 其他酚及酚醇的仅含卤素取代基的衍生物及其盐增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

2-溴苯酚文献

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Many weakly basic amine-containing drugs are known to be extensively sequestered in acidic lysosomes by an ion trapping-type mechanism. The entrapment of drugs in lysosomes has been shown to influence...

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Rotavirus increases levels of lipidated LC3 supporting accumulation of infectious progeny virus without inducing autophagosome formation.

PLoS ONE 9(4) , e95197, (2014)

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