4-氯邻苯二胺
4-氯邻苯二胺用途
用于有机合成。
4-氯邻苯二胺名称
[ CAS 号 ]:
95-83-0
[ 中文名 ]:
4-氯-1,2-苯二胺
[ 英文名 ]:
4-Chlorobenzene-1,2-diamine
[中文别名 ]:
[英文别名 ]:
- EINECS 202-456-8
- 4-Chloro-1,2-phenylenediamine
- 4-Chlorobenzene-1,2-diamine
- 4-Chloro-1,2-diaminobenzene
- 4-Chloro-1,2-benzenediamine
- MFCD00011691
- ZR BZ DG
- 1,2-Benzenediamine, 4-chloro-
4-氯邻苯二胺物理化学性质
[ 密度 ]:
1.3±0.1 g/cm3
[ 沸点 ]:
300.2±22.0 °C at 760 mmHg
[ 熔点 ]:
70-73 °C(lit.)
[ 分子式 ]:
C6H7ClN2
[ 分子量 ]:
142.586
[ 闪点 ]:
135.4±22.3 °C
[ 精确质量 ]:
142.029770
[ PSA ]:
52.04000
[ LogP ]:
1.15
[ 外观性状 ]:
棕色结晶固体或粉末
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.671
[ 储存条件 ]:
库房低温通风干燥,与强氧化剂分开存放
[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
[ 水溶解性 ]:
16 g/L (20 ºC)
4-氯邻苯二胺MSDS
4-氯邻苯二胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SS8850000
- CHEMICAL NAME :
- o-Phenylenediamine, 4-chloro-
- CAS REGISTRY NUMBER :
- 95-83-0
- BEILSTEIN REFERENCE NO. :
- 0508472
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 28
- MOLECULAR FORMULA :
- C6-H7-Cl-N2
- MOLECULAR WEIGHT :
- 142.60
- WISWESSER LINE NOTATION :
- ZR BZ DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 135 gm/kg/77W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 324 gm/kg/77W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 273 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 917 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 136 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 460 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 40500 gm/kg/96W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18750 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 14,207,1989 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,81,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,81,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993
4-氯邻苯二胺安全信息
[ 符号 ]:
GHS07, GHS08
[ 信号词 ]:
Warning
[ 危害声明 ]:
H315-H319-H335-H351
[ 警示性声明 ]:
P261-P281-P305 + P351 + P338
[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
Xn:Harmful;
[ 风险声明 (欧洲) ]:
R36/37/38;R40
[ 安全声明 (欧洲) ]:
S26-S36/37
[ 危险品运输编码 ]:
2811
[ WGK德国 ]:
3
[ RTECS号 ]:
SS8850000
[ 包装等级 ]:
I; II; III
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2921590090
4-氯邻苯二胺合成路线
4-氯邻苯二胺上下游产品
4-氯邻苯二胺上游产品
4-氯邻苯二胺下游产品
4-氯邻苯二胺海关
[ 海关编码 ]: 2921590090
[ 中文概述 ]:
2921590090. 其他芳香多胺及衍生物及它们的盐. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
4-氯邻苯二胺文献
Eur. J. Med. Chem. 44 , 3658-64, (2009)
A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above u...
4-Chloro-ortho-phenylenediamine and 4-chloro-meta-phenylenediamine.IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 27 , 81-9, (1982)
Carcinogenicity of 4-chloro-o-phenylenediamine, 4-chloro-m-phenylenediamine, and 2-chloro-p-phenylenediamine in Fischer 344 rats and B6C3F1 mice.
Carcinogenesis 1(6) , 495-9, (1980)
In both male and female Fischer rats, feeding 4-chloro-o-phenylenediamine at 0.5 or 1% in the diet led to a significant increase in hyperplasia, papilloma and carcinoma of the urinary bladder. Neoplas...
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产品详情:4-氯-1,2-苯二胺
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标题:4-氯邻苯二胺_MSDS_用途_密度_CAS号【95-83-0】_化源网 地址:https://www.chemsrc.com/amp/cas/95-83-0_752274.html