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苯并咪唑

苯并咪唑用途

Benzimidazole 是一种杂环芳香族有机化合物,是药物化学中重要的药效基团。Benzimidazole 衍生物具有抗癌、抗病毒、抗菌、抗真菌、抗寄生虫、抗炎、质子泵抑制剂、抗凝血等多种生物活性。

苯并咪唑名称

[ CAS 号 ]:
51-17-2

[ 中文名 ]:
苯并咪唑

[ 英文名 ]:
Benzimidazole

[中文别名 ]:

[英文别名 ]:

benzimidazol
monobenzimidazole
EINECS 200-081-4
Azindole
Benzoimidazole
1H-Benzo[d]imidazole
BZI
Benziminazole
MFCD00005585
Benzimidazole

苯并咪唑生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 流感病毒

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. V Yerragunta, et al. Benzimidazole Derivatives and Its Biological Importance: A Review, PharmaTutor, 2014, 2(3), 109-113.

[2]. Fei F, et al. New substituted benzimidazole derivatives: a patent review (2010 - 2012). Expert Opin Ther Pat. 2013 Sep;23(9):1157-79.

[3]. Wang M, et al. New substituted benzimidazole derivatives: a patent review (2013 - 2014). Expert Opin Ther Pat. 2015 May;25(5):595-612.

苯并咪唑物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
360.0±11.0 °C at 760 mmHg

[ 熔点 ]:
169-171 °C(lit.)

[ 分子式 ]:
C₇H₆N₂

[ 分子量 ]:
118.136

[ 闪点 ]:
208.4±5.7 °C

[ 精确质量 ]:
118.053101

[ PSA ]:
28.68000

[ LogP ]:
1.38

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.697

[ 储存条件 ]:
通风低温干燥

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidising agents.

[ 水溶解性 ]:
sparingly soluble

苯并咪唑MSDS

详细MSDS(安全技术说明书)

苯并咪唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD5425000

CHEMICAL NAME :: Benzimidazole

CAS REGISTRY NUMBER :: 51-17-2

BEILSTEIN REFERENCE NO. :: 0109682

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C7-H6-N2

MOLECULAR WEIGHT :: 118.15

WISWESSER LINE NOTATION :: T56 BM DNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 385 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2910 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 445 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Phage inhibition capacity

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 1 gm/L

REFERENCE :: ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960- Volume(issue)/page/year: 12,583,1972 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 32,151,1975

苯并咪唑安全信息

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S37/39-S26

[ WGK德国 ]:
3

[ RTECS号 ]:
DD5425000

[ 海关编码 ]:
2933990090

苯并咪唑合成路线

详细合成路线

苯并咪唑上下游产品

苯并咪唑上游产品

苯并咪唑下游产品

苯并咪唑制备

由邻苯二胺与甲酸经环合而得。将邻苯二胺与甲酸的混合物在水浴上加热2h，冷却，用10%氢氧化钠溶液调节pH至10，将析出的固体滤出，用冷水洗涤得粗品。粗品加水微沸，加活性炭脱色，趁热过滤，滤液冷至室温，过滤，冷水洗涤，在100℃干燥得成品。粗品收率90%。

半数致死量（小鼠，经口）2190mg/kg。

苯并咪唑海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%