草乃敌

草乃敌用途

Diphenamid is a chemical compound from the group of acetamides and a herbicide. The effect is based on inhibition of acetyl-CoA carboxylase. Do not confuse with anti-inflammatory agent difenpiramide.

草乃敌名称

[ CAS 号 ]:
957-51-7

[ 中文名 ]:
双苯酰草胺

[ 英文名 ]:
Diphenamid

[中文别名 ]:

[英文别名 ]:

DIPHENAMID
N,N-dimethyl-2,2-diphenyl-acetamide
Dymid
2,2-diphenyl-N,N-dimethylacetamide
rideon
EINECS 213-482-4
Dimid
zarur
u4513
ENIDE

草乃敌物理化学性质

[ 密度 ]:
1.07 g/cm3

[ 沸点 ]:
382.4ºC

[ 熔点 ]:
132-136 °C(lit.)

[ 分子式 ]:
C₁₆H₁₇NO

[ 分子量 ]:
239.31200

[ 闪点 ]:
173.3ºC

[ 精确质量 ]:
239.13100

[ PSA ]:
20.31000

[ LogP ]:
2.90670

[ 外观性状 ]:
白色或灰白色粉末

[ 储存条件 ]:
0-6°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases.

草乃敌MSDS

草乃敌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB8050000

CHEMICAL NAME :: Acetamide, N,N-dimethyl-2,2-diphenyl-

CAS REGISTRY NUMBER :: 957-51-7

BEILSTEIN REFERENCE NO. :: 2052009

LAST UPDATED :: 199710

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C16-H17-N-O

MOLECULAR WEIGHT :: 239.34

WISWESSER LINE NOTATION :: 1N1&VYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 685 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7280 mg/kg/26W-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

REFERENCE :: TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 16(1),45,1982 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84343 No. of Facilities: 95 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 374 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84343 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 41 (estimated) No. of Female Employees: 14 (estimated)

草乃敌安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H412

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22;R52/53

[ 安全声明 (欧洲) ]:
61

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AB8050000

[ 危险类别 ]:
3，6.1

[ 海关编码 ]:
2924299037

草乃敌合成路线

草乃敌上下游产品

草乃敌上游产品

草乃敌下游产品

草乃敌制备

二苯基三氯乙烷的制备将0.3molSG 、0.1mol三氯乙醛和0.1mol98%硫酸冷却至0～5℃，滴加0.3mol20%发烟硫酸，保持5～10℃，于2～4h滴毕，缓慢升温至室温，经后处理得二苯基三氯乙烷，收率80%。
二苯基乙酸的制备将0.1mol二苯基三氯乙烷用25g苯溶解后，于155～160℃滴入到含有50g乙二醇单乙醚和0.5mol氢氧化钠溶液中，约1h滴毕，继续加热反应5h，经后处理得二苯基乙酸，收率85%。
二苯基乙酰氯的制备将4.24g二苯基乙酸溶于35mL氯仿中，加2滴二甲基甲酰胺，3mL亚硫酰氯，于水浴中回流反应0.5h，排除反应产生的二氧化硫和氯化氢气体，蒸也氯仿后，冷却，加15mL苯，用于双苯酰草胺的制备。
双苯酰草胺的合成将2.84g二甲胺与25mL苯混合，加入上步反应制得的酰氯苯溶液，在水浴上回流2.5h，冷却后加20mL氯仿，经洗涤、干燥、回收溶剂得双苯酰草胺，上述两步收率85.8%。m.p. 130℃，用苯和石油醚混合液重结晶后m.p.133～135℃。

草乃敌海关

[ 海关编码 ]: 2924299037

[ 中文概述 ]:
2924299037. 虱螨脲、双苯酰草胺、双酰草胺等〔包括杀草隆、杀铃脲、杀螺胺、莎稗磷〕. 增值税率:17.0%. 退税率:9.0%. 监管条件:S(进出口农药登记证明). 最低关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2924299037 2-chloro-n-((4-(trifluoromethoxy)phenyl)carbamoyl)benzamide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

草乃敌文献

[Toxicologic characteristics of several pesticides and standards for them in water].

Probl. Khig. 8 , 116-20, (1983)

The progressive increase of production and application of chemicals for plant protection transmuted the problem of protection of water cleanliness into an international and national problem. The cases...

Determination of diphenamide, napropamide and metolachlor in tobacco by gel permeation chromatographic clean-up and high performance liquid chromatography.

Ann. Chim. 95(5) , 369-74, (2005)

Diphenamide, napropamide and metolachlor (FIG. 1) are selective, pre-emergence arylamide herbicides used to control the growth of annual grasses and broadleaf weeds in a variety of fields, e.g. fruit ...

[Data on establishing the maximum permissible concentration of difenamid in the air of a work area].

Gig. Sanit. (5) , 77-8, (1983)

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草乃敌