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地莫西泮

地莫西泮用途

Demoxepam 是 Chlordiazepoxide 的主要代谢产物。Demoxepam 对癌细胞系表现出细胞毒性活性。 Demoxepam 具有抗惊厥和抗焦虑作用。

地莫西泮名称

[ CAS 号 ]:
963-39-3

[ 中文名 ]:
地莫西泮

[ 英文名 ]:
Demoxepam

[中文别名 ]:

[英文别名 ]:

Demoxepam
CHLORDIAZEPOXIDE RELATED COMPOUND A
Ro 5-2092
Ro 5-2092 lactam
nordiazepam 4-oxide
Chlordiazepoxide lactam

地莫西泮生物活性

[ 描述 ]:

Demoxepam 是 Chlordiazepoxide 的主要代谢产物。Demoxepam 对癌细胞系表现出细胞毒性活性。 Demoxepam 具有抗惊厥和抗焦虑作用。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Moustapha Ouédraogo, et al. In vitro cytotoxicity study of oxaziridines generated after chlordiazepoxide, demoxepam, and desmethylchlordiazepoxide UV irradiation. Drug Chem Toxicol. 2009;32(4):417-23.

[2]. Gregory G Sarris, et al. Demoxepam Derivatization and GC-MS Analysis Produces Erroneous Nordiazepam and Oxazepam Results. J Anal Toxicol. 2019 Jun 1;43(5):406-410.

地莫西泮物理化学性质

[ 密度 ]:
1.37g/cm3

[ 沸点 ]:
447.4ºC at 760mmHg

[ 分子式 ]:
C₁₅H₁₁ClN₂O₂

[ 分子量 ]:
286.71300

[ 闪点 ]:
224.4ºC

[ 精确质量 ]:
286.05100

[ PSA ]:
57.85000

[ LogP ]:
2.73660

[ 折射率 ]:
1.682

地莫西泮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF1925000

CHEMICAL NAME :: 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-, 4-oxide

CAS REGISTRY NUMBER :: 963-39-3

BEILSTEIN REFERENCE NO. :: 0755892

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H11-Cl-N2-O2

MOLECULAR WEIGHT :: 286.73

WISWESSER LINE NOTATION :: T67 GMV JN IHJ CG JO KR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 7,590,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 26RAAN "Benzodinzenines," Garattini, S., et al., New York, Raven Press, 1973 Volume(issue)/page/year: -,39,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 7,590,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 7,590,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 628 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 7,590,1965

地莫西泮安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312 + H332-H319

[ 警示性声明 ]:
P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235

[ 危险品运输编码 ]:
UN 1648 3 / PGII

[ 海关编码 ]:
2933990090

地莫西泮合成路线

详细合成路线

地莫西泮上下游产品

地莫西泮上游产品

地莫西泮下游产品

地莫西泮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

地莫西泮文献

Liquid chromatography of demoxepam and phenothiazines using a post-column photochemical reactor and fluorescence detection.

J. Chromatogr. A. 217 , 463-71, (1981)

Upon irradiation with short-wavelength UV light the tranquillizer demoxepam is converted into a highly fluorescent product. This reaction serves as a sensitive and selective means of detection of low ...

The rapid hydrolysis of chlordiazepoxide to demoxepam may affect the outcome of chronic osmotic minipump studies.

Psychopharmacology 208(4) , 555-62, (2010)

In chronic studies, the classical benzodiazepine chlordiazepoxide (CDP) is often the preferred drug because, unlike other benzodiazepines, it is soluble in water. However, rapid CDP hydrolysis in solu...

Methods for the determination of lorazepam and chlordiazepoxide and metabolites in brain tissue. A comparison with plasma concentrations in the rat.

J. Chromatogr. A. 277 , 201-8, (1983)

Rapid and sensitive methods are described for determining lorazepam and for determining chlordiazepoxide and its metabolites in brain tissue of the rat. Lorazepam was determined by means of solvent ex...

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