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托吡酯

托吡酯用途

用作抗惊厥药、抗癫痫药

托吡酯名称

[ CAS 号 ]:
97240-79-4

[ 中文名 ]:
托吡酯

[ 英文名 ]:
Topiramate

[中文别名 ]:

[英文别名 ]:

Topamax Sprinkle
Topiramate
Topimax
Tipiramato [Spanish]
Epitomax
McN-4853
topiramatum [Latin]
topiramatum
Tipiramate [French]
Tipiramate

托吡酯生物活性

[ 描述 ]:

Topiramate是镇痉化合物,能拮抗GluR5受体,还可作为GABA受体介导的电流阳性变构调节剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体

研究领域 >> 神经疾病

[参考文献]

[1]. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56.

[2]. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7.

[3]. Ormrod D, et al. Topiramate: a review of its use in childhood epilepsy. Paediatr Drugs. 2001;3(4):293-319.

[相关活性小分子]

托吡酯物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
438.7±55.0 °C at 760 mmHg

[ 熔点 ]:
125ºC

[ 分子式 ]:
C₁₂H₂₁NO₈S

[ 分子量 ]:
339.362

[ 闪点 ]:
219.1±31.5 °C

[ 精确质量 ]:
339.098785

[ PSA ]:
123.92000

[ LogP ]:
2.97

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.497

[ 储存条件 ]:
0-10°C;避免加热

[ 水溶解性 ]:
可溶于：甲醇

托吡酯MSDS

详细MSDS(安全技术说明书)

托吡酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LS7083000

CAS REGISTRY NUMBER :: 97240-79-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H21-N-O8-S

MOLECULAR WEIGHT :: 339.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,342,1989

托吡酯安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ WGK德国 ]:
3

[ RTECS号 ]:
LS7083000

托吡酯合成路线

详细合成路线

托吡酯上下游产品

托吡酯上游产品

托吡酯下游产品

托吡酯文献

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

Kainic Acid-Induced Golgi Complex Fragmentation/Dispersal Shifts the Proteolysis of Reelin in Primary Rat Neuronal Cells: An In Vitro Model of Early Stage Epilepsy.

Mol. Neurobiol. , (2015)

The endoplasmic reticulum-lysosome-Golgi network plays an important role in Reelin glycosylation and its proteolytic processing. Golgi complex fragmentation is associated with the separation of Reelin...

Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis.

JAMA 311(18) , 1889-900, (2014)

Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused.To conduct a systematic review and meta-analysis of the be...

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托吡酯