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三磷酸腺苷二钠

三磷酸腺苷二钠用途

ATP是用于代谢反应中底物活化的磷酸基团供体和大量激酶的辅酶。

三磷酸腺苷二钠名称

[ CAS 号 ]:
987-65-5

[ 中文名 ]:
腺苷-5'-三磷酸二钠盐

[ 英文名 ]:
Adenosine 5'-triphosphate disodium salt

[中文别名 ]:

[英文别名 ]:

Adetphos
ATP disodium salt
Adinosine Triphosphate Disodium
UNII-5L51B4DR1G
ATP-Disodium Salt
adenosine triphosphate disodium
EINECS 213-579-1
ATP disodium
Adenosine 5'-(disodium triphosphate)
Trinosin

三磷酸腺苷二钠生物活性

[ 描述 ]:

ATP是用于代谢反应中底物活化的磷酸基团供体和大量激酶的辅酶。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> P2X受体

天然产物 >> 生物碱

研究领域 >> 代谢疾病

[参考文献]

[1]. Gordon, J.L., Extracellular ATP: effects, sources and fate. Biochem J, 1986. 233(2): p. 309-19.

[2]. Guibert, C., et al., Dependence of P2-nucleotide receptor agonist-mediated endothelium-independent relaxation on ectonucleotidase activity and A2A-receptors in rat portal vein. Br J Pharmacol, 1998. 123(8): p. 1732-40.

[3]. Burnstock, G., Historical review: ATP as a neurotransmitter. Trends Pharmacol Sci, 2006. 27(3): p. 166-76.

[相关活性小分子]

1-[N,O-二(5-异喹啉磺酰基)-N-甲基-L-型酪氨酸]-4-苯基哌嗪 | A-740003 | A 438079 | AF-353 | AZD9056盐酸盐 | PSB-12062 | A-317491 | A-804598 | 一个839977 | Gefapixant | GW791343(盐酸盐) | 高乌甲素 | CE-224535 | JNJ-54175446

三磷酸腺苷二钠物理化学性质

[ 密度 ]:
2.63g/cm3

[ 沸点 ]:
951.4ºC at 760mmHg

[ 熔点 ]:
188-190ºC

[ 分子式 ]:
C₁₀H₁₄N₅Na₂O₁₃P₃

[ 分子量 ]:
551.145

[ 精确质量 ]:
550.959656

[ PSA ]:
314.22000

[ 外观性状 ]:
固体

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 水溶解性 ]:
H2O: 50 mg/mL

三磷酸腺苷二钠MSDS

详细MSDS(安全技术说明书)

三磷酸腺苷二钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7417000

CHEMICAL NAME :: Adenosine 5'-(tetrahydrogen triphosphate), disodium salt

CAS REGISTRY NUMBER :: 987-65-5

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H14-N5-O13-P3.2Na

MOLECULAR WEIGHT :: 551.18

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ IZ D- BT5OTJ CQ DQ E1OPQO&OPQO&OPQQO &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,20,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,20,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,20,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,20,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,20,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 266 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,20,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9988 No. of Facilities: 45 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 308 (estimated) No. of Female Employees: 209 (estimated)

三磷酸腺苷二钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AU7417000

三磷酸腺苷二钠文献

Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton.

Sci. Rep. 6 , 19766, (2016)

The invasive blood-stage malaria parasite - the merozoite - induces rapid morphological changes to the target erythrocyte during entry. However, evidence for active molecular changes in the host cell ...

Induction of Posttranslational Modifications of Mitochondrial Proteins by ATP Contributes to Negative Regulation of Mitochondrial Function.

PLoS ONE 11 , e0150454, (2016)

It is generally accepted that ATP regulates mitochondrial function through the AMPK signaling pathway. However, the AMPK-independent pathway remains largely unknown. In this study, we investigated ATP...

DRAM1 regulates autophagy flux through lysosomes.

PLoS ONE 8 , e63245, (2013)

We have previously reported that the mitochondria inhibitor 3-nitropropionic acid (3-NP), induces the expression of DNA damage-regulated autophagy modulator1 (DRAM1) and activation of autophagy in rat...

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