L-酵母氨酸

L-酵母氨酸用途

Saccharopine (L-Saccharopine) 是赖氨酸的降解中间体,是一种线粒体毒素。赖氨酸-酮戊二酸还原酶将赖氨酸和 α-酮戊二酸转化为 Saccharopine。糖精脱氢酶将 Saccharopine 氧化为 α-氨基己酸酯半醛和谷氨酸。Saccharopine 通过破坏线粒体稳态而损害发育。

L-酵母氨酸名称

[ CAS 号 ]:
997-68-2

[ 中文名 ]:
L-酵母氨酸

[ 英文名 ]:
Saccharopine

[英文别名 ]:

L-SACCHAROPINE
L-Saccharopine

L-酵母氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[体外研究]

秀丽线虫α-氨基己二酸半醛合酶(AASS)-1的糖胞苷脱氢酶(SDH)突变导致线粒体损伤和功能丧失[1]。

[体内研究]

糖精嘌呤积累诱导Aass突变小鼠线粒体损伤和进行性出生后生长迟缓[1]。

[参考文献]

[1]. Zhou J, et, al. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. J Cell Biol. 2019 Feb 4;218(2):580-597.

[2]. Leandro J, et, al. Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin. J Cell Biol. 2019 Feb 4;218(2):391-392.

[3]. Papes F, et, al. Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. Biochem J. 1999 Dec 1;344 Pt 2(Pt 2):555-63.

L-酵母氨酸物理化学性质

[ 密度 ]:
1.333g/cm3

[ 沸点 ]:
537.2ºC at 760mmHg

[ 分子式 ]:
C₁₁H₂₀N₂O₆

[ 分子量 ]:
276.28600

[ 闪点 ]:
278.7ºC

[ 精确质量 ]:
276.13200

[ PSA ]:
149.95000

[ LogP ]:
0.56740

[ 折射率 ]:
1.537

L-酵母氨酸MSDS

详细MSDS(安全技术说明书)

L-酵母氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922499990

L-酵母氨酸上下游产品

L-酵母氨酸上游产品

L-酵母氨酸下游产品

L-酵母氨酸制备

1. 烟草：FC，52。

L-酵母氨酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

L-酵母氨酸文献

Attenuation of autophagic-proteolysis in C2C12 cells by saccharopine.

Mol. Cell Biochem. 410 , 93-100, (2015)

Muscle wasting impairs physical function and leads people to a bedridden state. We previously demonstrated that lysine (Lys) suppresses autophagic-proteolysis through the Akt pathway. However, the eff...

Molecular cloning and expression of human L-pipecolate oxidase.

Biochem. Biophys. Res. Commun. 270(3) , 1101-5, (2000)

In higher eukaryotes L-lysine can be degraded via two distinct routes including the saccharopine pathway and the L-pipecolate pathway. The saccharopine pathway is the primary route of degradation of l...

Lysine catabolism in Haemonchus contortus and Teladorsagia circumcincta.

Exp. Parasitol. 131(1) , 101-6, (2012)

Catabolism of lysine through the pipecolate, saccharopine and cadaverine pathways has been investigated in L3 and adult Haemonchus contortus and Teladorsagia circumcincta. Both enzymes of the saccharo...

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