中文名 | 普伐他汀 |
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英文名 | pravastatin |
中文别名 |
萘维太定
(+)-(3R,5R)-3,5-二羟基-7-[(1S,2S,6S,8S,8aR)-6-羟基-2-甲基-8-[(S)-2-甲基丁酰氧基]-1,2,6,7,8,8a-六氢-1-萘]-庚酸 (+)-(3R,5R)-3,5-二羟基-7-[(1S,2S,6S,8ΑR)-6-羟基-2-甲基-8-[(S)-2-甲基丁酰氧基]-1,2,6,7,8,8Α-六氢-1-萘基]庚酸钠 |
英文别名 |
(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]heptanoic acid
[14C]-Pravastatin Oliprevin MFCD00887601 Pravastatina (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid Pravachol Pravastatinum (3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid Pravastatin [3H]-Pravastatin Pravastatine [French] Pravastatina [Spanish] 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, (βR,δR,1S,2S,6S,8S,8aR)- (3R,5R)-3,5-dihydroxy-7-{(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyloxy]-1,2,6,7,8,8a-hexahydronaphthalen-1-yl}heptanoic acid Pravastatine Pravastatinum [Latin] Eptastatin |
描述 | Pravastatin是HMG-CoA还原酶抑制剂,对甾醇合成的IC50为5.6 μM。 |
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相关类别 | |
参考文献 |
密度 | 1.2±0.1 g/cm3 |
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沸点 | 634.5±55.0 °C at 760 mmHg |
熔点 | 171.2-173ºC |
分子式 | C23H36O7 |
分子量 | 424.53 |
闪点 | 213.2±25.0 °C |
PSA | 127.12000 |
LogP | 1.35 |
外观性状 | 白色粉末 |
蒸汽压 | 0.0±4.2 mmHg at 25°C |
折射率 | 1.555 |
储存条件 | 2-8°C |
水溶解性 | H2O: 19 mg/mL |
危害码 (欧洲) | F: Flammable;C: Corrosive; |
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风险声明 (欧洲) | R11;R34 |
安全声明 (欧洲) | S16-S26-S36/37/39-S45 |
WGK德国 | 2 |
RTECS号 | QJ7185000 |
~% 81093-37-0 |
文献:WO2005/121062 A2, ; Page/Page column 6 ; |
~88% 81093-37-0 |
文献:Biocon Limited; Tiwari, Sanjay; Patale, Mukesh Babuappa; Garg, Saurabh; Garg, Mayank Kumar; Joshi, Sulekha; Kumar, Chittnalli Ramegowda Naveen; Kumar, Bimal; Goel, Anuj; Iyer, Harish Patent: US2014/141467 A1, 2014 ; Location in patent: Page/Page column ; |
~% 81093-37-0 |
文献:Journal of Antibiotics, , vol. 50, # 12 p. 1032 - 1035 |
上游产品 2 | |
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下游产品 2 | |