123266-63-7

• 常用中文名：2,3-二氢-1-苯并呋喃-7-碳酰氯
• 常用英文名：2,3-dihydro-1-benzofuran-7-carbonyl chloride
• CAS号：123266-63-7
• 分子式：C₉H₇ClO₂
• 分子量：182.60400
• 发布时间：2018-12-28 18:22:28
• 更新时间：2024-01-03 08:55:41

名称

• 中文名: 2,3-二氢-1-苯并呋喃-7-碳酰氯
• 英文名: 2,3-dihydro-1-benzofuran-7-carbonyl chloride
• 中文别名: 2,3-二氢-1-苯并呋喃-7-羰酰氯; 2,3-二氢苯并呋喃-7-碳酰氯
• 英文别名: 2,3-dihydrobenzo[b]furan-7-oyl chloride; 2,3-Dihydro-7-benzofurancarboxylic acid chloride; 2,3-Dihydrobenzo[b]furan-7-carbonyl chloride; 2,3-dihydro-7-benzofurancarbonyl chloride; 2,3-DICHLORO-3'-[8-(1,4-DIOXA-8-AZASPIRO[4.5]DECYL)METHYL]BENZOPHENONE; 7-Benzofurancarbonylchloride,2,3-dihydro; 2,3-dihydrobenzofuran-7-carbonyl chloride

物化性质

• 密度: 1.342 g/cm3
• 沸点: 299.8ºC at 760 mmHg
• 分子式: C₉H₇ClO₂
• 分子量: 182.60400
• 闪点: 111.6ºC
• 精确质量: 182.01300
• PSA: 26.30000
• LogP: 2.00050
• 蒸汽压: 0.00116mmHg at 25°C
• 折射率: 1.586

MSDS

Name: 2 3-Dihydro-1-benzofuran-7-carbonyl chloride Material Safety Data Sheet Synonym: CAS: 123266-63-7 Section 1 - Chemical Product MSDS Name:2 3-Dihydro-1-benzofuran-7-carbonyl chloride Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 123266-63-7 2,3-Dihydro-1-benzofuran-7-carbonyl ch 95+% unlisted Hazard Symbols: C Risk Phrases: 14 29 35 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Reacts violently with water. Contact with water liberates toxic gas. Causes severe burns. Potential Health Effects Eye: Causes eye burns. Skin: Causes skin burns. Ingestion: Causes gastrointestinal tract burns. Inhalation: Causes chemical burns to the respiratory tract. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Do not induce vomiting. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use foam, dry chemical, or carbon dioxide. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood. Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 123266-63-7: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: Brown Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 55 - 60 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C9H7ClO2 Molecular Weight: 182.61 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents, water, strong bases. Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 123266-63-7 unlisted. LD50/LC50: Not available. Carcinogenicity: 2,3-Dihydro-1-benzofuran-7-carbonyl chloride - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: CORROSIVE SOLID, WATER REACTIVE, N.O.S.* Hazard Class: 8 UN Number: 3096 Packing Group: II IMO Shipping Name: CORROSIVE SOLID, WATER REACTIVE, N.O.S. Hazard Class: 8 UN Number: 3096 Packing Group: II RID/ADR Shipping Name: CORROSIVE SOLID, WATER REACTIVE, N.O.S. Hazard Class: 8 UN Number: 3096 Packing group: II Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: C Risk Phrases: R 14 Reacts violently with water. R 29 Contact with water liberates toxic gas. R 35 Causes severe burns. Safety Phrases: S 22 Do not breathe dust. S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 30 Never add water to this product. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 123266-63-7: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 123266-63-7 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 123266-63-7 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

合成路线

35700-40-4 ~% 123266-63-7

文献：Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L. Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319

79-37-8 35700-40-4 ~% 123266-63-7

文献：Pfizer INC Patent: US6207678 B1, 2001 ;

496-16-2 ~% 123266-63-7

文献：Murphy; Kung; Billings Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 171 - 178

13661-90-0 ~% 123266-63-7

文献：Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L. Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319

133844-95-8 ~% 123266-63-7

文献：Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L. Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319

75855-24-2 ~% 123266-63-7

文献：Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L. Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319

69-72-7 ~% 123266-63-7

文献：Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L. Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319

119-36-8 ~% 123266-63-7

文献：Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L. Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319

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