33817-20-8

• 常用中文名：匹凡西林
• 常用英文名：pivampicillin
• CAS号：33817-20-8
• 分子式：C₂₂H₂₉N₃O₆S
• 分子量：463.55
• 相关类别： 原料药 抗生素类药物 青霉素类药
• 发布时间：2018-06-19 09:55:07
• 更新时间：2024-01-04 11:42:05
• 匹匹西林是一种青霉素类抗生素。匹匹西林是氨苄青霉素(HY-B0522)的前药[1]。

名称

• 中文名: 匹凡西林
• 英文名: pivampicillin
• 中文别名: 匹氨西林
• 英文别名: Pivampicillin; 2,2-dimethylpropanoyloxymethyl (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; Pivaloyloxymethyl ampicillinate; Pivampicilline; Pondocillin; Pivampicilina; Pivampicillinum; Pivaloylampicillin; Ampicillin pivaloyloxymethyl ester

物化性质

• 密度: 1.33g/cm3
• 沸点: 679ºC at 760mmHg
• 分子式: C₂₂H₂₉N₃O₆S
• 分子量: 463.55
• 闪点: 364.5ºC
• 精确质量: 463.17800
• PSA: 153.33000
• LogP: 2.35260
• 折射率: 1.604
• 水溶解性: Practically insoluble in water, freely soluble in methanol, soluble in anhydrous ethanol. It dissolves in dilute acids.

生物活性

• 描述: 匹匹西林是一种青霉素类抗生素。匹匹西林是氨苄青霉素(HY-B0522)的前药[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Shi CK, et, al. Bactericidal composition and application thereof. CN109568323A.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XH8380000 CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-phenylacetamido)-3,3- dimethyl-7-oxo-, hydroxymethyl ester, pivalate (ester), D-(-)- CAS REGISTRY NUMBER : 33817-20-8 LAST UPDATED : 199706 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C22-H29-N3-O6-S MOLECULAR WEIGHT : 463.60 WISWESSER LINE NOTATION : T45 ANV ESTJ CMVYZR& F1 F1 GVO1OVX1&1&1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 900 mg/kg/90D-I TOXIC EFFECTS : Behavioral - muscle weakness Musculoskeletal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 68,932,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >6 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,310,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 148 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,310,1978

合成路线

18997-19-8 ~% 33817-20-8

文献：Journal of medicinal chemistry, , vol. 13, # 4 p. 607 - 612

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