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41826-92-0生产厂家

41826-92-0价格

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41826-92-0

41826-92-0结构式
41826-92-0结构式
  • 常用中文名：曲匹布通
  • 常用英文名：Trepibutone
  • CAS号：41826-92-0
  • 分子式：C16H22O6
  • 分子量：310.342
  • 相关类别： 原料药 消化系统用药 利胆药
  • 发布时间：2018-06-16 08:29:37
  • 更新时间：2024-01-02 05:51:07
  • 特立哌酮(AA 149)增加胆汁和胰液的分泌,加速胃肠道平滑肌松弛。特立哌酮可用于胆囊炎和功能性胃肠疾病的研究[1][2]。

化源商城直购

中文名 三醚丁酮酸
英文名 4-oxo-4-(2,4,5-triethoxyphenyl)butanoic acid
中文别名 3-(2,4,5-三乙氧基苯甲酰基)丙酸
曲匹布通
乙氧苯酰丙酸
英文别名 2,4,5-Triethoxy-g-oxobenzenebutanoic Acid
Colibil
Benzenebutanoic acid, 2,4,5-triethoxy-γ-oxo-
MFCD00865221
4-Oxo-4-(2,4,5-triethoxyphenyl)butanoic acid
Trepibutone
AA 149
Triethoxybenzoylpropionate
Supacal
描述 特立哌酮(AA 149)增加胆汁和胰液的分泌,加速胃肠道平滑肌松弛。特立哌酮可用于胆囊炎和功能性胃肠疾病的研究[1][2]。
相关类别
体外研究 特雷哌丁酮(1-1000μM)可显著放松Oddi和十二指肠的括约肌[1]。
体内研究 特立哌酮(1-20 mg/kg；静脉注射一次)剂量依赖性地增加胆汁流量[2]。特立哌酮(10mg/kg；注射14C-赤藓糖醇后3h静脉注射)刺激小管胆汁形成,而不会增加胆道和胆管中的水分分泌和抑制胆汁重吸收[2]。动物模型：麻醉比格犬[2]剂量：1-20 mg/kg给药：静脉注射；结果：剂量依赖性地增加了狗的胆汁流量,并在剂量为10mg/kg时显示出胆汁流量的峰值增加。动物模型：Beagle犬注射14C-赤藓糖醇[2]剂量：10mg/kg给药：静脉注射；10毫克/千克；注射14C-赤藓糖醇后3h结果：增加了与小管胆汁流相关的胆汁流,刺激了小管胆液的形成。
密度 1.1±0.1 g/cm3
沸点 498.6±45.0 °C at 760 mmHg
熔点 146-150ºC
分子式 C16H22O6
分子量 310.342
闪点 179.9±22.2 °C
精确质量 310.141632
PSA 82.06000
LogP 3.18
外观性状 淡黄色晶体粉末
蒸汽压 0.0±1.3 mmHg at 25°C
折射率 1.512
储存条件 室温， 密封， 干燥

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UF8440000
CHEMICAL NAME :
Propionic acid, 3-(2,4,5-triethoxybenzoyl)-
CAS REGISTRY NUMBER :
41826-92-0
LAST UPDATED :
199612
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C16-H22-O6
MOLECULAR WEIGHT :
310.38
WISWESSER LINE NOTATION :
QV2VR BO2 DO2 EO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,811,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,811,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
570 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,811,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,811,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1310 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,1501,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
510 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,1501,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
625 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,1501,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,811,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9100 mg/kg/30D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Endocrine - changes in thymus weight Blood - hemorrhage
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 36,263,1977
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
45500 mg/kg/26W-C
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 36,263,1977

海关编码 2918990090
3878-55-5结构式

3878-55-5

41827-15-0结构式

41827-15-0

~%

41826-92-0结构式

41826-92-0

文献：Murata; Satoh; Nohara; et al. European Journal of Medicinal Chemistry, 1977 , vol. 12, # 1 p. 17 - 20
上游产品  2

下游产品  1

海关编码 2918990090
中文概述 2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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