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322-35-0

322-35-0结构式
322-35-0结构式

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中文名 苄丝肼
英文名 benserazide
中文别名 DL-丝氨酰(2,3,4-三羟基苄基)肼盐酸盐
三羟苄基丝氨酰肼
2-氨基-3-羟基-2'-(2,3,4-三羟基苄基)丙酰肼
英文别名 bensarazide
Benseraszide
Ro 4-4602
Benserazida
DL-Seryltrihydroxybenzylhydrazine
MFCD00242633
2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide
Serazide
Benserazidum
描述 Benserazide 是一种 PKM2 抑制剂。 Benserazide 直接结合并阻断 PKM2 酶活性,从而抑制有氧糖酵解,同时上调 OXPHOS。Benserazide可用于黑色素瘤的研究。
相关类别
参考文献

[1]. Zhou Y, et al. Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment. Int J Cancer. 2020 Jul 1;147(1):139-151.  

密度 1.541 g/cm3
沸点 574.2ºC at 760 mmHg
分子式 C10H15N3O5
分子量 257.24300
闪点 301ºC
精确质量 257.10100
PSA 148.07000
折射率 1.678

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VT9632200
CHEMICAL NAME :
Serine, 2-(2,3,4-trihydroxybenzyl)hyrazide, DL-
CAS REGISTRY NUMBER :
322-35-0
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H15-N3-O5
MOLECULAR WEIGHT :
257.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
23400 mg/kg/90D-C
TOXIC EFFECTS :
Behavioral - ataxia Kidney, Ureter, Bladder - other changes in urine composition Musculoskeletal - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2880 mg/kg
SEX/DURATION :
female 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982

危害码 (欧洲) Xi
风险声明 (欧洲) R36/37/38
安全声明 (欧洲) S26
海关编码 2928000090
海关编码 2928000090
中文概述 2928000090 其他肼(联氨)及胲(羟胺)的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%