31528-44-6

31528-44-6结构式

中文名	霉酸Β-D-葡萄糖醛酸
英文名	mycophenolic acid glucuronide
英文别名	5-[(2E)-5-Carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl b-D-Glucopyranosiduronic Acid MYCOPHENOLIC ACID B-D-GLUCURONIDE Mycophenolic Acid-D-Glucuronide Mycophenolic Acid Glucosiduronate 5-[(2E)-5-Carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl-D-Glucopyranosiduronic Acid

描述	霉酚酸葡糖苷酸是免疫抑制剂霉酚酸(MPA)的代谢物。霉酚酸葡糖苷酸具有抗肿瘤活性,可用于腺癌研究[1][2][3]。
相关类别	研究领域 >> 癌症信号通路 >> 其他 >> 其他
体外研究	霉酚酸葡糖苷酸显示弱IMP脱氢酶(IMPDH)II型抑制,IC50为3.3 mg/L[3]。
体内研究	霉酚酸葡糖苷酸(腹腔注射；6mg/小鼠；两天一次；6d)治疗可降低Ehrlich小鼠自发性腺癌模型中的肿瘤生长[2]。动物模型：瑞士白化系小鼠植入Ehrlich腹水肿瘤细胞[2]剂量：6mg/小鼠给药：腹腔注射；6 mg/小鼠；两天一次；6d结果：与未治疗对照组相比,肿瘤抑制率为76.8%。
参考文献	[1]. Natascha A Wolff, et al. Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of the human kidney. Nephrol Dial Transplant. 2007 Sep;22(9):2497-503. [2]. Ando K, et al. Synthesis of mycophenolic acid beta-D-glucuronide and its antitumor activity. J Antibiot (Tokyo). 1970 Aug;23(8):408-13. [3]. Gensburger O, et al. Effect of mycophenolate acyl-glucuronide on human recombinant type 2 inosine monophosphate dehydrogenase. Clin Chem. 2009 May;55(5):986-93.

密度	1.502g/cm3
沸点	875.7ºC at 760mmHg
熔点	98-100ºC
分子式	C₂₃H₂₈O₁₂
分子量	496.46100
闪点	299.6ºC
精确质量	496.15800
PSA	189.28000
LogP	0.29860
外观性状	固体
折射率	1.624
储存条件	Hygroscopic, -20°C Freezer, Under Inert Atmosphere