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武汉敬康恩生物医药科技有限公司
湖北省武汉市东西湖区
产品名：Oxymetazoline
纯度：98.0%
规格：1g
联系人：周经理
联系电话：15871494362

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1491-59-4生产厂家

1491-59-4价格

1491-59-4

1491-59-4结构式

常用中文名：羟甲唑啉
常用英文名：Oxymetazoline
CAS号：1491-59-4
分子式：C₁₆H₂₄N₂O
分子量：260.37500
相关类别：信号通路 G 蛋白偶联受体/G 蛋白肾上腺素能受体
发布时间：2018-02-20 08:00:00
更新时间：2024-01-06 20:03:09
羟甲唑啉是一种α-肾上腺素受体激动剂,α1A、α1B、α2A和α2C的IC50s分别为0.02μM、0.25μM、o.58μM和0.13μM。奥昔他唑啉可用于研究鼻粘膜的解充血作用[1]。

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中文名	羟甲唑啉
英文名	oxymetazoline
中文别名	2-(3-羟基-2,6-二甲基-4-叔丁基苄基)-2-咪唑啉氧甲唑啉阿弗林 6-叔丁基-3-(4,5-二氢-1H-咪唑-2-基甲基)-2,4-二甲基苯酚 [羟间唑啉]
英文别名	Oximetazolinum EINECS 216-079-1 Rhinofrenol 3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-6-tert-butylphenol MFCD00242798 Iliadin Oxymethazoline 2-(4-t-butyl-2,6-dimethyl-3-hydroxy-benzyl)-2-imidazoline Sinerol 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-phenol Oxylazine Nezeril Hazol Nafrine

描述	羟甲唑啉是一种α-肾上腺素受体激动剂,α1A、α1B、α2A和α2C的IC50s分别为0.02μM、0.25μM、o.58μM和0.13μM。奥昔他唑啉可用于研究鼻粘膜的解充血作用[1]。
相关类别	研究领域 >> 其他信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
靶点	IC50: 0.02 μM (α1A), 0.25 μM (α1B), 0.58 μM (α2A), 0.13 μM (α2C)[1]
参考文献	[1]. Haenisch B, et al. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.

密度	1.08 g/cm3
沸点	431.9ºC at 760 mmHg
熔点	182ºC
分子式	C₁₆H₂₄N₂O
分子量	260.37500
闪点	215ºC
精确质量	260.18900
PSA	44.62000
LogP	2.61510
蒸汽压	4.59E-08mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SK1050000

CHEMICAL NAME :: Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-

CAS REGISTRY NUMBER :: 1491-59-4

BEILSTEIN REFERENCE NO. :: 0886303

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H24-N2-O

MOLECULAR WEIGHT :: 260.42

WISWESSER LINE NOTATION :: T5M CN BUTJ B1R CQ B1 F1 DX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,74,1967 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 20 mg/kg

SEX/DURATION :: female 1-5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 11,563,1975

危险品运输编码	UN 3249
包装等级	II
危险类别	6.1(a)
海关编码	2933290090

海关编码	2933290090
中文概述	2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%