10310-32-4

• 常用中文名：三苄糖苷
• 常用英文名：Tribenoside
• CAS号：10310-32-4
• 分子式：C₂₉H₃₄O₆
• 分子量：478.57700
• 相关类别： 生物化工 糖类化合物 单糖
• 发布时间：2018-03-28 08:00:00
• 更新时间：2024-01-04 11:14:30
• 苯三糖苷是一种血管保护剂,可用于痔疮的研究。三苯皂苷具有温和的抗炎、镇痛和伤口愈合特性[1]。

名称

• 中文名: 三苄糖苷
• 英文名: (3R,4R,5R)-5-[1,2-bis(phenylmethoxy)ethyl]-2-ethoxy-4-phenylmethoxyoxolan-3-ol
• 中文别名: (3R,4R,5R)-5-[1,2-双(苯甲氧基)乙基]-2-乙氧基-4-(苯甲氧基)氧杂戊环-3-醇; 三苄糖甙; 三苄糖甙
• 英文别名: Tribenosido [INN-Spanish]; TBGF; Tribenzoside; Tribenosidum [INN-Latin]; Glivenol; ethyl-3,5,6-tri-O-benzyl-D-glucofuranoside; EINECS 233-687-2; tribenoside; Glyvenal; Glyvenol

物化性质

• 密度: 1.19g/cm3
• 沸点: 618.9ºC at 760mmHg
• 分子式: C₂₉H₃₄O₆
• 分子量: 478.57700
• 闪点: 328.1ºC
• 精确质量: 478.23600
• PSA: 66.38000
• LogP: 4.49630
• 蒸汽压: 3.55E-16mmHg at 25°C
• 折射率: 1.59
• 储存条件: -20°C

生物活性

• 描述: 苯三糖苷是一种血管保护剂,可用于痔疮的研究。三苯皂苷具有温和的抗炎、镇痛和伤口愈合特性[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: 三苯皂苷(1nm-100µM)对HeLa细胞具有细胞毒性作用,EC50为13.74µM[2]。细胞活力测定[2]细胞系：HeLa细胞浓度：1nm、10nm、100nm、1µM、10µM、100µM培养时间：72小时结果：HeLa细胞活力以剂量反应性方式降低。
• 体内研究: 三苯皂苷(每周口服500和1200 mg/kg剂量)显著降低骨质疏松症的发生[3]。动物模型：雄性C57黑小鼠[3]剂量：500和1200 mg/kg每周给药：口服给药结果：导致整个关节受累显著减少。
• 参考文献:

  [1]. Yamato Kikkawa, et al. The influence of Tribenoside on expression and deposition of epidermal laminins in HaCaT cells. Biol Pharm Bull. 2010;33(2):307-10.

  [2]. Yu-Chen Lo, et al. Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential. Sci Rep. 2017 Sep 12;7(1):11261.

  [3]. G Wilhelmi, et al. Suitability of the C57 black mouse as an experimental animal for the study of skeletal changes due to ageing, with special reference to osteo-arthrosis and its response to tribenoside. Pharmacology. 1976;14(4):289-96.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LZ4993000 CHEMICAL NAME : Glucofuranoside, ethyl-3,5,6-tri-o-benzyl-, D- CAS REGISTRY NUMBER : 10310-32-4 LAST UPDATED : 199603 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C29-H34-O6 MOLECULAR WEIGHT : 478.63 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >20 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2748,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2748,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >20 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2748,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >30 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2748,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2748,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >30 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2748,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 84 gm/kg/2W-I TOXIC EFFECTS : Liver - changes in liver weight REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2789,1974 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 65 gm/kg/30D-I TOXIC EFFECTS : Liver - fatty liver degeneration Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2748,1974 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 156 gm/kg/26W-I TOXIC EFFECTS : Liver - fatty liver degeneration Liver - changes in liver weight Endocrine - changes in adrenal weight REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2772,1974 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 84 gm/kg/2W-I TOXIC EFFECTS : Liver - changes in liver weight Endocrine - changes in spleen weight Endocrine - changes in thymus weight REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2789,1974

安全

• 危险品运输编码: NONH for all modes of transport