52133-67-2

• 常用中文名：2-氰基-4,4-二乙氧基丁酸乙酯
• 常用英文名：Ethyl 2-cyano-4,4-diethoxybutyrate
• CAS号：52133-67-2
• 分子式：C₁₁H₁₉NO₄
• 分子量：229.273
• 发布时间：2018-12-24 11:39:33
• 更新时间：2024-01-12 11:08:27

名称

• 中文名: 2-氰基-4,4-二乙氧基丁酸乙酯
• 英文名: Ethyl 2-cyano-4,4-diethoxybutyrate
• 英文别名: Butanoic acid, 2-cyano-4,4-diethoxy-, ethyl ester; Ethyl-2,2-diethoxythylcyanoacetate; Ethyl 2,2-Diethoxyethylcyanoacetate; Ethyl 2-cyano-4,4-diethoxybutanoate; Ethyl 2-Cyano-4,4-diethoxybutyrate; MFCD02094250

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 335.2±42.0 °C at 760 mmHg
• 分子式: C₁₁H₁₉NO₄
• 分子量: 229.273
• 闪点: 146.1±18.1 °C
• 精确质量: 229.131409
• PSA: 68.55000
• LogP: 2.14
• 外观性状: 无色液体
• 蒸汽压: 0.0±0.7 mmHg at 25°C
• 折射率: 1.440
• 储存条件: Refrigerator

MSDS

Name: Ethyl 2-cyano-4,4-diethoxybutanoate Material Safety Data Sheet Synonym: CAS: 52133-67-2 Section 1 - Chemical Product MSDS Name: Ethyl 2-cyano-4,4-diethoxybutanoate Material Safety Data Sheet Synonym: SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 52133-67-2 Ethyl 2-cyano-4,4-diethoxybutanoate unlisted Hazard Symbols: XI Risk Phrases: 36/37/38 SECTION 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. SECTION 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. SECTION 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. SECTION 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. SECTION 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 52133-67-2: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Liquid Color: colorless Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: 86 deg C @ 0.1mmHg Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: > 110 deg C (> 230.00 deg F) Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Slightly soluble. Specific Gravity/Density: 1.0248 Molecular Formula: C11H19NO4 Molecular Weight: 229.28 SECTION 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong acids, strong bases, strong oxidizing agents, strong reducing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported SECTION 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 52133-67-2 unlisted. LD50/LC50: Not available. Carcinogenicity: Ethyl 2-cyano-4,4-diethoxybutanoate - Not listed by ACGIH, IARC, or NTP. SECTION 12 - ECOLOGICAL INFORMATION SECTION 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. SECTION 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. SECTION 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 52133-67-2: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 52133-67-2 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 52133-67-2 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION MSDS Creation Date: 4/03/2003 Revision #0 Date: Original. The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): 26-36/37/39

合成路线

105-56-6 2032-35-1 ~74% 52133-67-2

文献：Kim, Jiae; Wang, Ligong; Li, Yongfeng; Becnel, Kimberlynne D.; Frey, Kathleen M.; Garforth, Scott J.; Prasad, Vinayaka R.; Schinazi, Raymond F.; Liotta, Dennis C.; Anderson, Karen S. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4064 - 4067

64-17-5 1187-46-8 109-92-2 ~61% 52133-67-2

文献：Kita, Yasuyuki; Sano, Atsunori; Yamaguchi, Takahiro; Oka, Masahisa; Gotanda, Kentoku; Matsugi, Masato Journal of Organic Chemistry, 1999 , vol. 64, # 2 p. 675 - 678

105-56-6 621-62-5 ~49% 52133-67-2

文献：Gangjee, Aleem; Wang, Ying; Queener, Sherry F.; Kisliuk, Roy L. Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1523 - 1531

上下游产品

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109-92-2 621-62-5
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