3403-25-6

• 常用中文名：D-苯丙氨酸叔丁酯盐酸盐
• 常用英文名：H-D-Phe-Obut HCl
• CAS号：3403-25-6
• 分子式：C₁₃H₂₀ClNO₂
• 分子量：257.756
• 相关类别： 生物化工 氨基酸及其衍生物 苯丙氨酸类衍生物
• 发布时间：2018-07-15 06:58:57
• 更新时间：2024-01-02 14:12:35
• H-D-Phe-OtBu。HCl是苯丙氨酸衍生物[1]。

名称

• 中文名: D-苯丙氨酸叔丁酯盐酸盐
• 英文名: tert-butyl (2R)-2-amino-3-phenylpropanoate,hydrochloride
• 中文别名: D-(+)-对甲基二苯甲酰酒石酸
• 英文别名: tert-butyl (R)-phenylalaninate hydrochloride; D-Phenylalanine, 1,1-dimethylethyl ester, hydrochloride (1:1); H-D-Phe-OtBu hydrochloride; H-D-Phe-OtBu.HCl; L-phenylalanine tert-butyl ester hydrochloride; D-Phenylalanine tert-butyl ester hydrochloride; H-D-Phe-OtBu.HCI; 2-Methyl-2-propanyl phenylalaninate hydrochloride (1:1); (R)-tert-Butyl 2-amino-3-phenylpropanoate hydrochloride; Phenylalanine, 1,1-dimethylethyl ester, hydrochloride (1:1); D-phenylalanine tert-butyl ester hydrochloride salt; tert-butyl D-phenylalaninate hydrochloride; H-D-Phe-Otbu Hcl; H-D-Phe-OtBu inverted exclamation mark currencyHCl; tert-Butyl D-phenylalaninate hydrochloride (1:1); tert-Butyl L-phenylalaninate hydrochloride (1:1); 2-Methyl-2-propanyl D-phenylalaninate hydrochloride (1:1); H-D-Phe-Obut HCl

物化性质

• 沸点: 336.9ºC at 760 mmHg
• 熔点: 208-211ºC
• 分子式: C₁₃H₂₀ClNO₂
• 分子量: 257.756
• 闪点: 157.6ºC
• 精确质量: 257.118256
• PSA: 52.32000
• LogP: 3.40040
• 外观性状: Solid
• 储存条件: 0-6°C
• 水溶解性: Soluble in water.

生物活性

• 描述: H-D-Phe-OtBu。HCl是苯丙氨酸衍生物[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体外研究: 氨基酸和氨基酸衍生物已被商业化用作能量补充剂。它们影响合成代谢激素的分泌、运动期间的燃料供应、压力相关任务期间的精神表现,并防止运动引起的肌肉损伤。它们被认为是有益的能生膳食物质[1]。
• 参考文献:

  [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-920.

MSDS

Material Safety Data Sheet Section1. Identification of the substance H-D-Phe-OtBu HCl Product Name: Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. H319:Causes serious eye irritation H412:Harmful to aquatic life with long lasting effects P273:Avoid release to the environment P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing Section3. Composition/information on ingredients. Ingredient name:H-D-Phe-OtBu HCl CAS number:3403-25-6 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage This product should be handled only by, or under the close supervision of, those properly qualified Handling: in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Storage:Store in closed vessels. Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data Melting point:No data Flash point:No data Density:No data Molecular formula: C13H19NO2.ClH Molecular weight: 257.8 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36
• 安全声明 (欧洲): 26
• 海关编码: 2922499990

合成路线

673-06-3 115-11-7 ~79% 3403-25-6

文献：Tetrahedron, , vol. 41, # 23 p. 5633 - 5636

226900-30-7 ~% 15100-75-1 3403-25-6

文献：Tetrahedron, , vol. 57, # 13 p. 2491 - 2498

上下游产品

上游产品  2
673-06-3 115-11-7
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海关

海关编码	2922499990
中文概述	2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%