372-66-7

• 常用中文名：6-氨基-2-甲基-2-庚醇
• 常用英文名：Heptaminol
• CAS号：372-66-7
• 分子式：C₈H₁₉NO
• 分子量：145.24300
• 相关类别： 化学试剂 有机试剂 脂肪醇
• 发布时间：2018-05-29 08:00:00
• 更新时间：2024-01-06 16:29:35

名称

• 中文名: 6-氨基-2-甲基-2-庚醇
• 英文名: 6-amino-2-methylheptan-2-ol
• 中文别名: 庚胺醇
• 英文别名: 2-Methyl-2-hydroxy-6-aminoheptane; 6-Amino-2-methyl-2-heptanol; 2-amino-6-hydroxy-6-methyl-heptane; EINECS 206-758-0; heptaminol; 2-HEPTANOL,6-AMINO-2-METHYL; MFCD00127893

物化性质

• 密度: 0.895g/cm3
• 沸点: 250.1ºC at 760mmHg
• 分子式: C₈H₁₉NO
• 分子量: 145.24300
• 闪点: 105.1ºC
• 精确质量: 145.14700
• PSA: 46.25000
• LogP: 1.97510
• 外观性状: Oily Liquid | Clear colorless
• 折射率: 1.455-1.457
• 储存条件:

  密封储存，储存于阴凉、干燥的库房。

• 稳定性: 常温常压下稳定，避免与不相容材料接触。 与强氧化剂反应。
• 计算化学:

  1.疏水参数计算参考值（XlogP）:0.7

  2.氢键供体数量:2

  3.氢键受体数量:2

  4.可旋转化学键数量:4

  5.互变异构体数量:无

  6.拓扑分子极性表面积46.2

  7.重原子数量:10

  8.表面电荷:0

  9.复杂度:91.3

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：无色油状胺味液体

  2. 密度（g/mL, 25 ℃ ）：2.317

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,11.2515mmHg）：115

  7. 折射率(n20/D)：1.455-1.457（lit.）

  8. 闪点（ºF）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（mmHg,25ºC）：未确定

  12. 饱和蒸气压（kPa,83-85ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：可混溶的

MSDS

Name: 6-Amino-2-methyl-2-heptanol 98% Material Safety Data Sheet Synonym: Heptaminol; 2-Methyl-2-hydroxy-6-aminoheptan CAS: 372-66-7 Section 1 - Chemical Product MSDS Name:6-Amino-2-methyl-2-heptanol 98% Material Safety Data Sheet Synonym:Heptaminol; 2-Methyl-2-hydroxy-6-aminoheptan Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 372-66-7 6-Amino-2-methyl-2-heptanol 98.0 206-758-0 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Antidote: None reported. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 372-66-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Liquid Color: oily, colorless Odor: amine-like pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: 92 - 93 deg C @ 7.00mm Hg Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: miscible Specific Gravity/Density: .8950g/cm3 Molecular Formula: C8H19NO Molecular Weight: Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stability unknown. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 372-66-7: MJ3230000 LD50/LC50: Not available. Carcinogenicity: 6-Amino-2-methyl-2-heptanol - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 372-66-7: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 372-66-7 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 372-66-7 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1、急性毒性：小鼠经静脉LD50：1250mg/kg； 生态学数据: 对环境有危害，对水体有污染，禁止进入水体。 CHEMICAL IDENTIFICATION RTECS NUMBER : MJ3230000 CHEMICAL NAME : 2-Heptanol, 6-amino-2-methyl- CAS REGISTRY NUMBER : 372-66-7 BEILSTEIN REFERENCE NO. : 1209267 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C8-H19-N-O MOLECULAR WEIGHT : 145.28 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 230,142,1957

安全

• 危害码 (欧洲): C: Corrosive;
• 风险声明 (欧洲): 34
• 安全声明 (欧洲): 45-36/37/39-26
• 海关编码: 2922199090

合成路线

165962-54-9 ~% 372-66-7

文献：El Blidi, Lahssen; Nechab, Malek; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard Journal of Organic Chemistry, 2009 , vol. 74, # 7 p. 2901 - 2903

90227-28-4 ~% 372-66-7

文献：Fujita et al. Ann. Rep. Tanabe pharm. Res.Chem.Abstr., 1959 , vol. 4, # 2 p. 15,19 Ann. Rep. Tanabe pharm. Res.Chem.Abstr., 1960 , p. 8627

352641-49-7 ~% 372-66-7

文献：Doeuvre; Poizat Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1947 , vol. 224, p. 288

110-93-0 ~% 372-66-7

文献：Doeuvre; Poizat Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1947 , vol. 224, p. 288

上下游产品

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165962-54-9 90227-28-4 110-93-0
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1118-51-0 165962-54-9 1100754-09-3 1100753-90-9
85602-77-3

海关

海关编码	2922199090
中文概述	2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%