27262-45-9

• 常用中文名：(R)-盐酸布比卡因
• 常用英文名：D-(+)-Bupivacaine
• CAS号：27262-45-9
• 分子式：C₁₈H₂₈N₂O
• 分子量：288.428
• 发布时间：2018-06-24 19:22:07
• 更新时间：2024-01-10 14:20:27

名称

• 中文名: (R)-(+)-丁哌卡因盐酸盐
• 英文名: dextrobupivacaine
• 中文别名: (R)-盐酸布比卡因
• 英文别名: 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, (2R)-; (R)-(+)-BUPIVACAINE; (2R)-1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide; (2R)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide; (+)-Bupivacaine; (+)-(R)-Bupivacaine; (R)-Bupivacaine; Bupivacaine Impurity 2

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 423.4±45.0 °C at 760 mmHg
• 分子式: C₁₈H₂₈N₂O
• 分子量: 288.428
• 闪点: 209.9±28.7 °C
• 精确质量: 288.220154
• PSA: 32.34000
• LogP: 3.64
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.547
• 储存条件: 库房通风低温干燥,与食品原料类分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TK6080000 CHEMICAL NAME : 2',6'-Pipecoloxylidide, 1-butyl-, D-(+)- CAS REGISTRY NUMBER : 27262-45-9 LAST UPDATED : 199112 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C18-H28-N2-O MOLECULAR WEIGHT : 288.48 WISWESSER LINE NOTATION : T6NTJ A4 BVMR B1 F1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 38 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 31,273,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 31,273,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 31,273,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 31,273,1972 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 5500 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 31,273,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,78,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intratracheal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,78,1976

安全

• 海关编码: 2933399090

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海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%