CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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EB3150000
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CHEMICAL NAME :
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Bismuth, trimethyl-
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CAS REGISTRY NUMBER :
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593-91-9
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BEILSTEIN REFERENCE NO. :
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3902984
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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10
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MOLECULAR FORMULA :
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C3-H9-Bi
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MOLECULAR WEIGHT :
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254.10
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WISWESSER LINE NOTATION :
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1-BI-1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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233 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,17,1939
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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233 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,17,1939
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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233 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - nausea or vomiting
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,17,1939
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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182 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,17,1939
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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12 mg/kg
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TOXIC EFFECTS :
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Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,17,1939
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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484 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,17,1939
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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182 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,17,1939
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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11 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity)
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,17,1939
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Bird - pigeon
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DOSE/DURATION :
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6 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Vascular - shock Gastrointestinal - nausea or vomiting
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,17,1939 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4627 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)
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