62-90-8

• 常用中文名：苯丙酸诺龙
• 常用英文名：Nandrolone phenylpropionate
• CAS号：62-90-8
• 分子式：C₂₇H₃₄O₃
• 分子量：406.557
• 相关类别： 原料药 激素及调节内分泌功能类药 雄激素及同化激素类药
• 发布时间：2018-02-05 08:00:00
• 更新时间：2024-01-02 18:36:41
• 【用途一】
  用于发育不良、营养失调、消耗性疾患的治疗。

名称

• 中文名: 苯丙酸诺龙
• 英文名: nandrolone phenpropionate
• 中文别名: 苯丙酸诺龙; 苯丙酸诺酮 usp限制; 19-去甲基睾丸素苯丙酸酯
• 英文别名: Nandrolone phenpropionate; 17b-Hydroxyestr-4-en-3-one 3-Phenylpropionate; Benzenepropanoic acid, (17β)-3-oxoestr-4-en-17-yl ester; EINECS 200-551-9; Superanabolon; Estr-4-en-3-one, 17- (1-oxo-3-phenylpropoxy)-, (17β)-; 19-Nor-17b-hydroxy-3-ketoandrostene 17-Phenylpropionate; Nandrolin; Strabolene; (17b)-(1-Oxo-3-phenylpropoxy)estr-4-en-3-one; 19-Norandrostenolone phenylpropionate; 19-Nortestosterone b-Phenylpropionate; Estr-4-ene-3-one, 17-β-hydroxy-, 3-phenylpropionate; Estr-4-en-3-one, 17-(1-oxo-3-phenylpropoxy)-, (17β)-; Nandrolone phenylpropionate; 19-Nor-D4-androsten-17b-ol-3-one b-Phenylpropionate; MFCD00198407; (17β)-3-Oxoestr-4-en-17-yl 3-phenylpropanoate; Activin; Durabol; 17b-hydroxyestr-4-en-3-one 17-(3-phenylpropionate); 17b-Hydroxy-4-estren-3-one Hydrocinnamate; 19-Nortestosterone, hydrocinnamate

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 546.9±50.0 °C at 760 mmHg
• 熔点: 93-99ºC
• 分子式: C₂₇H₃₄O₃
• 分子量: 406.557
• 闪点: 234.6±30.2 °C
• 精确质量: 406.250793
• PSA: 43.37000
• LogP: 5.97
• 外观性状: 白色或乳状的结晶粉末
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.577
• 储存条件: Controlled Substance, -20?C Freezer
• 分子结构:

  1、 摩尔折射率：117.38

  2、 摩尔体积（cm³/mol）：354.0

  3、 等张比容(90.2K)：927.8

  4、 表面张力(dyne/cm)：47.1

  5、 极化率(10-24cm³)：46.53

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KG7995000 CHEMICAL NAME : Estr-4-en-3-one, 17-beta-hydroxy-, hydrocinnamate CAS REGISTRY NUMBER : 62-90-8 BEILSTEIN REFERENCE NO. : 3170861 LAST UPDATED : 199612 DATA ITEMS CITED : 15 MOLECULAR FORMULA : C27-H34-O3 MOLECULAR WEIGHT : 406.61 WISWESSER LINE NOTATION : L E5 B666 OV MUTJ E1 FOV2R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 595 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 20,143,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,541,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 14850 ug/kg SEX/DURATION : male 11 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,1673,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 60 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 18,731,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 600 mg/kg SEX/DURATION : female 17-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : AVBIB9 Advances in the Biosciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1967- Volume(issue)/page/year: 13,71,1974 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 1400 ug/kg SEX/DURATION : male 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,907,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 3750 ug/kg SEX/DURATION : female 9-14 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 15 mg/kg SEX/DURATION : female 9-14 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - live birth index (measured after birth) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 1200 ug/kg SEX/DURATION : female 3 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,907,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 15 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - live birth index (measured after birth) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 15 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 60 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 240 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973 *** REVIEWS *** TOXICOLOGY REVIEW BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 8,259,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5317 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 314 (estimated)

安全

• 符号: GHS07, GHS08
• 信号词: Warning
• 危害声明: H302 + H312-H351
• 警示性声明: P280-P301 + P312 + P330
• 危害码 (欧洲): F,Xi
• 风险声明 (欧洲): R36/37/38:Irritating to eyes, respiratory system and skin .
• 安全声明 (欧洲): S7-S16-S37/39-S26-S36
• 危险品运输编码: UN 1170 3/PG 2
• WGK德国: 3
• 海关编码: 2942000000

海关

海关编码	2942000000