93965-89-0

93965-89-0结构式

英文名	1-29-Somatoliberin (human pancreatic islet), N-acetyl-2-D-phenylalanine-29-L-argininamide
英文别名	N-AC-TYR(1)-PHE(2)-SOMATOTROPIN RELEASING HORMONE (1-29)-AMIDE L-Argininamide, N-acetyl-L-tyrosyl-D-phenylalanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl- L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-methionyl-L-seryl- NBI 35965 hydrochloride N-Acetyl-L-tyrosyl-D-phenylalanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl -L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-methionyl-L-seryl-L-argininamide Somatoliberin (human pancreatic islet), N-acetyl-2-D-phenylalanine-29-L-argininamide-30-de-L-glutamine-31-de-L-glutamine-32-deglycine-33-de-L-glutamic acid-34-de-L-serine-35-de-L-asparagine-36-de-L-glutamine-37-de-L-glutamic acid-38-de-L-arginine-39-deglycine-40-de-L-alanine-41-de-L-arginine-42-de-L-alanine-43-de-L-arginine-44-de-L-leucinamide-

描述	[Ac-Tyr1,D-Phe2]GRF 1-29,酰胺(人),一种生长激素释放因子(GRF)类似物,是一种血管活性肠肽(VIP)拮抗剂[1]。
相关类别	研究领域 >> 心血管疾病信号通路 >> 其他 >> 其他
靶点	VIP[1]
体外研究	[Ac-Tyr1,D-Phe2]GRF 1-29,酰胺(人)选择性抑制贵宾和 GRF公司刺激的大鼠胰腺浆膜腺苷酸环化酶活性[1]。 [Ac-Tyr1,D-Phe2]GRF 1-29,酰胺(人)(0.1 pM-10 nM；3 D)诱导第6页细胞的剂量依赖性细胞增殖增加[2]。细胞增殖测定[2]细胞系：C6大鼠胶质母细胞瘤细胞浓度：0.1 pM-10 nM培养时间：3天结果：诱导剂量依赖性细胞增殖增加。
参考文献	[1]. Waelbroeck M, et al. Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist. Endocrinology. 1985 Jun;116(6):2643-9. [2]. Dufes C, et al. Effects of the vasoactive intestinal peptide (VIP) and related peptides on glioblastoma cell growth in vitro. J Mol Neurosci. 2003;21(2):91-102.