298-59-9

• 常用中文名：盐酸哌甲酯
• 常用英文名：methylphenidate hydrochloride
• CAS号：298-59-9
• 分子式：C₁₄H₂₀ClNO₂
• 分子量：269.767
• 相关类别： 原料药 神经系统用药 其它神经系统用药
• 发布时间：2018-06-25 17:51:33
• 更新时间：2024-01-05 19:20:19
• Methylphenidate hydrochloride is a central nervous system (CNS) stimulant, that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.

名称

• 中文名: 盐酸哌甲酯
• 英文名: methylphenidate hydrochloride
• 中文别名: alpha-苯基-2-哌啶乙酸甲酯盐酸盐
• 英文别名: Methyl 2-phenyl-2-(piperidin-2-yl)acetate hydrochloride; Methyl (2S)-phenyl[(2S)-2-piperidinyl]acetate hydrochloride (1:1); Ciba 4311b; Concerta; Methylphenidate hydrochloride; EINECS 206-065-3; Methyl phenyl(2-piperidinyl)acetate hydrochloride (1:1); 2-Piperidineacetic acid, α-phenyl-, methyl ester, hydrochloride (1:1); Metadate; Methyl a-Phenyl-a-(2-piperidyl)acetate Hydrochloride; METHYLPHENIDATE.HCl; 2-Piperidineacetic acid, α-phenyl-, methyl ester, hydrochloride, (R*,R*)- (±)-; a-Phenyl-a-(2-piperidyl)acetic Acid Methyl Ester Hydrochloride; 2-Piperidineacetic acid, α-phenyl-, methyl ester, (αS,2S)-, hydrochloride (1:1); a-Phenyl-2-piperidineacetic Acid Methyl Ester Hydrochloride; Methyl α-phenyl-2-piperidineacetate hydrochloride; Methyl phenyl(piperidin-2-yl)acetate hydrochloride (1:1); methylphenidate HCl; MFCD00058191; 2-Piperidineacetic acid, α-phenyl-, methyl ester, hydrochloride; Ritalin hydrochloride

物化性质

• 沸点: 327.6ºC at 760 mmHg
• 熔点: 224 - 226ºC
• 分子式: C₁₄H₂₀ClNO₂
• 分子量: 269.767
• 闪点: 152ºC
• 精确质量: 269.118256
• PSA: 38.33000
• LogP: 3.21610
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.000199mmHg at 25°C
• 折射率: 1.523
• 储存条件: Store at RT
• 稳定性: Stable. Combustible. Incompatible with strong oxidizing agents, alkalies, barbiturates.

MSDS

Section 1. Chemical Product and Company Identification Methylphenidate Hydrochloride Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Chemical Name Chemical Family Methylphenidate Hydrochloride Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature 550°C (1022°F) Flash PointsNot available. Flammable LimitsNot available. These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Products of Combustion Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various SubstancesNon-flammable in presence of open flames and sparks. Explosion Hazards in Presence Slightly explosive in presence of open flames and sparks. of Various SubstancesNon-explosive in presence of shocks. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onAs with most organic solids, fire is possible at elevated temperatures Fire Hazards Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust Hazardsexplosion hazard. Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large Spill Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Methylphenidate Hydrochloride Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as alkalis. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid.OdorOdorless. Not available. Taste Molecular Weight269.77 g/mole White. Color Not available. pH (1% soln/water) Boiling PointNot available. Melting Point224°C (435.2°F) Critical TemperatureNot available. Specific GravityNot available. Not applicable. Vapor Pressure Vapor DensityNot available. Not available. Volatility Odor ThresholdNot available. Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Dispersion PropertiesSee solubility in water, methanol. SolubilityEasily soluble in cold water, methanol. Very slightly soluble in acetone. Soluble in alcohol. Slightly soluble in Chloroform. Methylphenidate Hydrochloride Section 10. Stability and Reactivity Data The product is stable. Stability Instability TemperatureNot available. Heat, incompatible materials Conditions of Instability Reactive with alkalis. Incompatibility with various substances CorrosivityNot available. Special Remarks onNot available. Reactivity Special Remarks onNot available. Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryAbsorbed through skin. Inhalation. Ingestion. Toxicity to AnimalsAcute oral toxicity (LD50): 60 mg/kg [Mouse]. Chronic Effects on Humans May cause damage to the following organs: cardiovascular system, central nervous system (CNS). Other Toxic Effects onHazardous in case of ingestion, of inhalation. HumansSlightly hazardous in case of skin contact (irritant, sensitizer, permeator). Special Remarks onNot available. Toxicity to Animals Special Remarks onMay cause cancer based on animal test data. Chronic Effects on Humans May affect genetic material (mutagenic) Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. It may be absorbed through broken skin. Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation and cause sneezing, coughing, hypersensitivity and other symptoms similar to ingestion. Ingestion: Harmful if swallowed. It is a narcotic. It may cause nausea, stomach pain, dry mouth, and vomiting. It may affect behavior/central nervous system, cardiovascular system, urinary system, brain, liver, blood. Other adverse health effects may include: fast heartbeat, heart palpitations, increased blood pressure, irregular heart beat, bruising, skin rash, fever, sweating, loss of appetite, uncontrolled movements, joint pain, nervousness, dizziness, sleepiness, agitiation, insomnia, confusion, tremors, muscle twitching, delirium, hallucinations, sense of well-being, convulsions possibly followed by coma. Chronic Potential Health Effects: Skin: Repeated or prolonged skin contact may cause hypersensitivity. Ingestion: Repeated or prolonged ingestion may cause habituation or addiction. Prolonged or repeated ingestion may also cause sensitization (hypersensitivity) and develop skin rashes, coughs, stuffy nose, asthma, and other allergic reactions. Hypersensitivity may develop immediately after contact or after years of exposure. Prolonged ingestion may also cause weight loss. Medical conditions aggravated by exposure: severe anxiety, tension or agitation, severe depression, glaucoma, motor tics, Tourette's Syndrome, and high blood pressure. Methylphenidate Hydrochloride Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The products of degradation are less toxic than the product itself. Toxicity of the Products of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). Not applicable. Identification Not applicable. Special Provisions for Transport DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms No products were found. Federal and State Regulations CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: No products were found. Proposition 65 Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsOSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)R22- Harmful if swallowed.S2- Keep out of the reach of children. S46- If swallowed, seek medical advice immediately and show this container or label. Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E Methylphenidate Hydrochloride WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Methylphenidate Hydrochloride All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TM3850000 CHEMICAL NAME : 2-Piperidineacetic acid, alpha-phenyl-, methyl ester, hydrochloride CAS REGISTRY NUMBER : 298-59-9 LAST UPDATED : 199712 DATA ITEMS CITED : 22 MOLECULAR FORMULA : C14-H19-N-O2.Cl-H MOLECULAR WEIGHT : 269.80 WISWESSER LINE NOTATION : T6MTJ BYR&VO1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 32 mg/kg/6W-I TOXIC EFFECTS : Behavioral - toxic psychosis TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 170 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 96500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 170 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6370 mg/kg/13W-C TOXIC EFFECTS : Brain and Coverings - changes in brain weight Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5320 mg/kg/14D-C TOXIC EFFECTS : Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6370 mg/kg/13W-C TOXIC EFFECTS : Liver - other changes Liver - changes in liver weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 28 mg/kg/14D-C TOXIC EFFECTS : Liver - changes in liver weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 18250 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors MUTATION DATA TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 702 mg/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6175 No. of Facilities: 46 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 697 (estimated) No. of Female Employees: 366 (estimated)

安全

• 符号: GHS07, GHS08
• 信号词: Danger
• 危害声明: H302-H334
• 警示性声明: P261-P342 + P311
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R22;R42
• 安全声明 (欧洲): 22-26-36
• 危险品运输编码: UN 3249
• WGK德国: 3
• RTECS号: TM3850000
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2933399090

合成路线

113-45-1 113-45-1 ~58% 298-59-9

文献：US2004/176412 A1, ; Page/Page column 5-6 ;

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海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%