129273-38-7

• 常用中文名：盐酸哌罗匹隆
• 常用英文名：Perospirone hydrochloride
• CAS号：129273-38-7
• 分子式：C₂₃H₃₁ClN₄O₂S
• 分子量：463.036
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
• 发布时间：2018-08-21 08:18:40
• 更新时间：2024-01-02 18:31:53
• Perospirone hydrochloride (SM-9018) 是具有口服活性的 5-HT2A 受体 (Ki 为 0.6 nM) 和多巴胺 D2 受体 (Ki 为 1.4 nM) 的拮抗剂,也是 5-HT1A 受体 (Ki 为 2.9 nM) 的部分激动剂。Perospirone hydrochloride 是一种非典型的抗精神病剂,可用于精神分裂症的研究。

名称

• 中文名: 盐酸哌罗匹隆
• 英文名: Perospirone Hydrochloride Trihydrate
• 中文别名: N-{4-[4-(1,2-苯并噻唑-3-基)-1-哌嗪]丁基}环己-1,2-二甲酰亚胺盐酸盐
• 英文别名: MFCD08457543; Perospirone hydrochloride; (3aR,7aS)-2-{4-[4-(1,2-Benzothiazol-3-yl)-1-piperazinyl]butyl}hexahydro-1H-isoindole-1,3(2H)-dione hydrochloride (1:1); 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)-, hydrochloride (1:1)

物化性质

• 沸点: 667.4ºC at 760 mmHg
• 熔点: 95-970ºC
• 分子式: C₂₃H₃₁ClN₄O₂S
• 分子量: 463.036
• 闪点: 357.4ºC
• 精确质量: 462.185638
• PSA: 84.99000
• LogP: 4.11650
• 外观性状: 白色固体
• 储存条件: -20°C Freezer

生物活性

• 描述: Perospirone hydrochloride (SM-9018) 是具有口服活性的 5-HT2A 受体 (Ki 为 0.6 nM) 和多巴胺 D2 受体 (Ki 为 1.4 nM) 的拮抗剂,也是 5-HT1A 受体 (Ki 为 2.9 nM) 的部分激动剂。Perospirone hydrochloride 是一种非典型的抗精神病剂,可用于精神分裂症的研究。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点:

  5-HT2A Receptor:0.6 nM (Ki)

  D2 Receptor:1.4 nM (Ki)

  5-HT1A Receptor:2.9 nM (Ki)

  5-HT1 Receptor:18 nM (Ki)

  D1 Receptor:41 nM (Ki)

• 参考文献:

  [1]. Kato T, et al. Binding profile of SM-9018, a novel antipsychotic candidate. pn J Pharmacol. 1990 Dec;54(4):478-81.

  [2]. Hagiwara H, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. Eur Neuropsychopharmacol. 2008 Jun;18(6):448-54.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NR3397915 CHEMICAL NAME : 1H-Isoindole-1,3(2H)-dione, 2-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl )hexahydro-, monohydrochloride, cis- CAS REGISTRY NUMBER : 129273-38-7 LAST UPDATED : 199806 DATA ITEMS CITED : 7 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 870 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - hair REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 31,177,1997 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 33 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 31,177,1997 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 660 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 31,177,1997 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 31,201,1997 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9125 mg/kg/1Y-I TOXIC EFFECTS : Liver - other changes Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 31,309,1997 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 2275 mg/kg/13W-I TOXIC EFFECTS : Behavioral - tremor Endocrine - changes in thymus weight Blood - changes in leukocyte (WBC) count REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 31,201,1997 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 1820 mg/kg/52W-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - somnolence (general depressed activity) Behavioral - tremor REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 31,309,1997