36376-47-3

• 常用中文名：2-(4-甲基-1H-咪唑-5-基)乙胺盐酸盐
• 常用英文名：4-Methylhistamine dihydrochloride
• CAS号：36376-47-3
• 分子式：C₆H₁₃Cl₂N₃
• 分子量：198.09400
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 组胺受体
• 发布时间：2018-06-11 07:47:36
• 更新时间：2024-01-03 08:38:13
• 4-甲基组胺(盐酸)是组胺4受体(H4R)的有效激动剂。4-甲基组胺(二氢氯化物)具有研究癌症和自身免疫性疾病等免疫相关疾病的潜力[1]。

名称

• 中文名: 2-(4-甲基-1H-咪唑-5-基)乙胺双盐酸盐
• 英文名: 2-(5-methyl-1H-imidazol-4-yl)ethanamine,dihydrochloride
• 英文别名: 2-<5-methyl-1H-imidazol-4-yl>ethanamine dihydrochloride; 5-metilistamina diclorinato; 5-Methylhistamine dihydrochloride; 5-Methyl-1H-imidazole-4-ethanamine dihydrochloride; 2-methylhistamine dihydrochloride; 5-metilistamina dicloridrato; 4-Methylhistamine dihydrochloride

物化性质

• 密度: 1.1g/cm3
• 沸点: 345ºC at 760 mmHg
• 分子式: C₆H₁₃Cl₂N₃
• 分子量: 198.09400
• 闪点: 189.3ºC
• 精确质量: 197.04900
• PSA: 54.70000
• LogP: 2.52360
• 折射率: 1.558
• 储存条件: 2-8°C

生物活性

• 描述: 4-甲基组胺(盐酸)是组胺4受体(H4R)的有效激动剂。4-甲基组胺(二氢氯化物)具有研究癌症和自身免疫性疾病等免疫相关疾病的潜力[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> 组胺受体
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 靶点:

  histamine 4 receptor[1]

• 参考文献:

  [1]. Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NI3505800 CHEMICAL NAME : Imidazole, 4-(2-aminoethyl)-5-methyl-, dihydrochloride CAS REGISTRY NUMBER : 36376-47-3 LAST UPDATED : 199206 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C6-H11-N3.2Cl-H MOLECULAR WEIGHT : 198.12 WISWESSER LINE NOTATION : T5M CNJ D2Z E1 &GH 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 991 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - pleural effusion REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 77,54,1943 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 198 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 77,54,1943

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933290090

合成路线

120231-08-5 ~86% 36376-47-3

文献：Davey, D. D.; Lumma, W. C. Journal of Organic Chemistry, 1989 , vol. 54, # 13 p. 3211 - 3213

75815-57-5 ~% 36376-47-3

文献：Journal of Organic Chemistry, , vol. 54, # 13 p. 3211 - 3213

75815-55-3 ~% 36376-47-3

文献：Journal of Organic Chemistry, , vol. 54, # 13 p. 3211 - 3213

75815-53-1 ~% 36376-47-3

文献：Journal of Organic Chemistry, , vol. 54, # 13 p. 3211 - 3213

120231-07-4 ~% 36376-47-3

文献：Journal of Organic Chemistry, , vol. 54, # 13 p. 3211 - 3213

120231-06-3 ~% 36376-47-3

文献：Journal of Organic Chemistry, , vol. 54, # 13 p. 3211 - 3213

上下游产品

上游产品  6
120231-08-5 75815-57-5 75815-55-3 75815-53-1
120231-07-4 120231-06-3
下游产品  0

海关

海关编码	2933290090
中文概述	2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%