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19202-92-7

19202-92-7结构式

常用中文名：團菊素
常用英文名：Tenulin
CAS号：19202-92-7
分子式：C₁₆H₂₀O₅
分子量：292.32700
相关类别：研究领域其他
发布时间：2018-04-21 08:00:00
更新时间：2024-01-18 10:36:19
Tenulin是一种倍半萜内酯。Tenulin可以从Helenium amarum中分离出来[1]。

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中文名	團菊素
英文名	2H-1,4-Dioxadicyclopent[cd,f]azulene-3,9-dione, 2a,4a,5,6,6a,9a,9b,9c-octahydro-2-hydroxy-2,2a,6,9a-tetramethyl

描述	Tenulin是一种倍半萜内酯。Tenulin可以从Helenium amarum中分离出来[1]。
相关类别	研究领域 >> 其他信号通路 >> 其他 >> 其他
参考文献	[1]. G W Ivie, et al. Toxicity and milk bittering properties of tenulin, the major sesquiterpene lactone constituent of Helenium amarum (bitter sneezeweed). J Agric Food Chem. 1975 Sep-Oct;23(5):845-9. J Agric Food Chem. 1975 Sep-Oct;23(5):845-9.

密度	1.263g/cm3
沸点	490.4ºC at 760mmHg
分子式	C₁₆H₂₀O₅
分子量	292.32700
闪点	180.3ºC
精确质量	292.13100
PSA	72.83000
LogP	1.05270
蒸汽压	1.13E-11mmHg at 25°C
折射率	1.55

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BD9640000

CHEMICAL NAME :: Ambros-2-en-12-oic acid, 6-beta,13-epoxy-8-alpha,13-dihydroxy-11-methyl-4-oxo- , gamma-lactone

CAS REGISTRY NUMBER :: 19202-92-7

LAST UPDATED :: 199012

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C17-H22-O5

MOLECULAR WEIGHT :: 306.39

WISWESSER LINE NOTATION :: T C5755 1A O DV KOV OO EUTJ C1 H1 N1Q N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) Gastrointestinal - peritonitis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 2143 umol/L

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,1235,1978