785804-17-3

• 常用中文名：Abarelix acetate
• 常用英文名：Abarelix acetate
• CAS号：785804-17-3
• 分子式：C₇₄H₉₉ClN₁₄O₁₆
• 分子量：1476.115
• 发布时间：2021-01-12 19:44:25
• 更新时间：2024-01-19 11:15:08
• Abarelix acetate is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It increases histamine release from rat peritoneal mast cells in vitro and from a human skin model ex vivo. In vivo, abarelix decreases plasma luteinizing hormone (LH) levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hours.3 Abarelix (2 mg/kg) also transiently decreases plasma testosterone levels in intact rats, with levels returning to baseline within seven days post-treatment. Formulations containing abarelix have previously been used in the treatment of advanced prostate cancer.

名称

• 英文名: Abarelix (acetate)
• 英文别名: Abarelix (acetate); D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-D-asparaginyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-, acetate ( 1:1); MFCD17011970; N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-D-asparaginyl-L-leucyl-N6-isopropyl-L-lysyl-L-prolyl-D-alaninamide acetate (1:1)

物化性质

• 分子式: C₇₄H₉₉ClN₁₄O₁₆
• 分子量: 1476.115
• 精确质量: 1474.705200