474-74-8

• 常用中文名：甘氨石胆酸
• 常用英文名：Glycolithocholic acid
• CAS号：474-74-8
• 分子式：C₂₆H₄₃NO₄
• 分子量：433.62400
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-08-23 17:42:32
• 更新时间：2024-01-05 18:34:47
• 甘胆酸是一种内源性代谢产物,是一种甘氨酸结合的次级胆汁酸。糖石胆酸可用于诊断溃疡性结肠炎(UC)、非酒精性脂肪性肝炎(NASH)和原发性硬化性胆管炎(PSC)[1][2][3][4]。

名称

• 中文名: 甘氨石胆酸
• 英文名: glycolithocholic acid
• 英文别名: Glycolithocholic acid; 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid; Lithocholic acid glycine conjugate; Lithocholylglycine; Glycolithocholate

物化性质

• 密度: 1.112g/cm3
• 沸点: 619.7ºC at 760mmHg
• 熔点: 212-214°C (lit.)
• 分子式: C₂₆H₄₃NO₄
• 分子量: 433.62400
• 闪点: 328.6ºC
• 精确质量: 433.31900
• PSA: 86.63000
• LogP: 5.01420
• 储存条件: 2-8°C

生物活性

• 描述: 甘胆酸是一种内源性代谢产物,是一种甘氨酸结合的次级胆汁酸。糖石胆酸可用于诊断溃疡性结肠炎(UC)、非酒精性脂肪性肝炎(NASH)和原发性硬化性胆管炎(PSC)[1][2][3][4]。
• 相关类别:
  研究领域 >> 炎症/免疫
• 体内研究: 溃疡性结肠炎(UC)患者的糖石胆酸浓度显著低于健康对照组(HCs)[2]。
• 参考文献:

  [1]. Tanno N, et, al. Biliary lipid composition in heterozygous familial hypercholesterolemia and influence of treatment with probucol. Dig Dis Sci. 1994 Jul;39(7):1586-91.

  [2]. Ang ZH, et, al. Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis. World J Gastroenterol. 2021 Jun 28;27(24):3609-3629.

  [3]. Bansal S, et, al. Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites. J Pharmacol Exp Ther. 2019 Jun;369(3):389-405.

  [4]. Sanyal AJ, et, al. Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases. JHEP Rep. 2021 Feb 19;3(3):100255.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MC0594200 CHEMICAL NAME : Glycine, N-((3-alpha,5-beta)-3-hydroxy-24-oxocholan-24-yl)- CAS REGISTRY NUMBER : 474-74-8 LAST UPDATED : 199509 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C26-H43-N-O4 MOLECULAR WEIGHT : 433.70 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : DNA adduct TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 10 mg/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 15,1911,1994

安全

• 危害码 (欧洲): T