78628-81-6

• 常用中文名：特比萘芬 im B
• 常用英文名：(Z)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
• CAS号：78628-81-6
• 分子式：C₂₁H₂₅N
• 分子量：291.430
• 发布时间：2018-06-29 10:41:04
• 更新时间：2024-01-03 23:56:44

名称

• 中文名: 特比萘芬 im B
• 英文名: (Z)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
• 英文别名: (Z)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine; Terbinafine hydrochloride specified impurity B [EP]; Terbinafine,(Z); Terbinafine related compound B free base; AC1LU7MV; (Z)-N,6,6-trimethyl-N-(naphth-1-ylmethyl)hept-2-en-4-yn-1-amine; N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethyl amine; 1-Naphthalenemethanamine, N-[(2Z)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-; Terbinafine hydrochloride impurity,cis-terbinafine-[USP]; cis-Terbinafine; 1-Naphthalenemethanamine,N-((2Z)-6,6-dimethyl-2-hepten-4-ynyl)-N-methyl; (2Z)-N,6,6-Trimethyl-N-(1-naphthylmethyl)-2-hepten-4-yn-1-amine; UNII-S76S370M70; (2Z)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 417.9±33.0 °C at 760 mmHg
• 分子式: C₂₁H₂₅N
• 分子量: 291.430
• 闪点: 183.7±22.3 °C
• 精确质量: 291.198700
• PSA: 3.24000
• LogP: 6.61
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.586

合成路线

704909-67-1 917-92-0 134865-58-0 ~% 91161-71-6 详细

文献：DINAMITE DIPHARMA S.P.A., IN ABBREVIATED FORM DIPHARMA S.P.A. Patent: WO2004/50604 A2, 2004 ; Location in patent: Page 7 ;

14489-75-9 635708-74-6 ~64% 78628-81-6

文献：Kazakov; Golosov Pharmaceutical Chemistry Journal, 2006 , vol. 40, # 8 p. 452 - 454

917-92-0 ~% 78628-81-6

文献：Stuetz, Anton; Petranyi, Gabor Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1539 - 1543

14489-75-9 78629-20-6 ~% 91161-71-6 78628-81-6

文献：Stuetz, Anton; Petranyi, Gabor Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1539 - 1543

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