223652-90-2

• 常用中文名：甲磺酸加雷沙星一水合物
• 常用英文名：Garenoxacin Mesylate
• CAS号：223652-90-2
• 分子式：C₂₄H₂₆F₂N₂O₈S
• 分子量：540.534
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-07-15 18:58:54
• 更新时间：2024-01-13 18:52:51
• Garenoxacin甲磺酸盐水合物是一种新型的口服des-fluoro(6)喹诺酮, 具有强的抗菌活性, 抗常见呼吸道病原体, 包括耐药菌株。

名称

• 中文名: 甲磺酸加雷沙星一水合物
• 英文名: 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid,methanesulfonic acid,hydrate
• 中文别名: 1-环丙基-8-(二氟甲氧基)-7-[(1R)-2,3-二氢-1-甲基-1H-异吲哚-5-基]-1,4-二氢-4-氧代-3-喹啉甲酸甲磺酸盐一水合物; 甲磺酸加雷沙星
• 英文别名: Garenoxacin mesilate; Garenoxacin mesylate hydrate; 3-Quinolinecarboxylic acid, 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-, methanesulfonate, hydrate (1:1:1); BMS-284756-01; T-3811ME; Inforce; 1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate hydrate (1:1:1); Garenoxacin Mesylate; Geninax; 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-5-isoindolyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate monohydrate; Garenoxacin (Mesylate hydrate)

物化性质

• 沸点: 581.5ºC at 760 mmHg
• 分子式: C₂₄H₂₆F₂N₂O₈S
• 分子量: 540.534
• 精确质量: 540.137817
• PSA: 152.54000
• LogP: 5.31650
• 蒸汽压: 2.29E-14mmHg at 25°C
• 储存条件: 2-8℃

生物活性

• 描述: Garenoxacin甲磺酸盐水合物是一种新型的口服des-fluoro(6)喹诺酮, 具有强的抗菌活性, 抗常见呼吸道病原体, 包括耐药菌株。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Waites KB, et al. In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas. Antimicrob Agents Chemother. 2003 Jan;47(1):161-5.

  [2]. Ince D, et al. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother. 2002 Nov;46(11):3370-80.

  [3]. Zhao X, et al. Mutant prevention concentration of garenoxacin (BMS-284756) for ciprofloxacin-susceptible or -resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2003 Mar;47(3):1023-7.