8011-96-9

• 常用中文名：炉甘石
• 常用英文名：calamine
• CAS号：8011-96-9
• 分子式：Fe₂O₄Zn
• 分子量：241.06800
• 相关类别： 原料药 专科用药 皮肤科用药
• 发布时间：2017-04-20 09:02:33
• 更新时间：2024-01-05 16:42:09

名称

• 中文名: 水锌矿(菱锌矿,异矿)
• 英文名: zinc,iron(3+),oxygen(2-)
• 中文别名: 炉甘石
• 英文别名: Calamine (pharmaceutical preparation); Primer; Reliamed; Repara; Calamine lotion; Iron oxide (Fe2O3),mixture with zinc oxide; Calamine [USP:JAN]; Medipack; Tenderwrap

物化性质

• 分子式: Fe₂O₄Zn
• 分子量: 241.06800
• 精确质量: 239.77900
• 外观性状: 固体
• 储存条件: 室温
• 稳定性: Stable.
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:4

  4.可旋转化学键数量:0

  5.互变异构体数量:无

  6.拓扑分子极性表面积:4

  7.重原子数量:7

  8.表面电荷:0

  9.复杂度:0

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:7

MSDS

Section 1. Chemical Product and Company Identification Calamine Common Name/ Trade Name Calamine Section 4. First Aid Measures Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least Eye Contact 15 minutes. Get medical attention if irritation occurs. Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Skin Contact Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Not available. Serious Inhalation Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an Ingestion unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Not available. Serious Ingestion Section 5. Fire and Explosion Data Flammability of the Product Non-flammable. Auto-Ignition Temperature Not applicable. Not applicable. Flash Points Not applicable. Flammable Limits Not available. Products of Combustion Fire Hazards in Presence of Not applicable. Various Substances Risks of explosion of the product in presence of mechanical impact: Not available. Explosion Hazards in Risks of explosion of the product in presence of static discharge: Not available. Presence of Various Substances Not applicable. Fire Fighting Media and Instructions Slow addition of zinc oxide to cover linseed oil varnish causes generation of heat and ignition. Special Remarks on Fire Hazards May explode when mixed with chlorinated rubber. Special Remarks on Zinc Oxide and Magnesium can react explosively when heated. Explosion Hazards Section 6. Accidental Release Measures Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading Small Spill water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on Large Spill the contaminated surface and allow to evacuate through the sanitary system. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Calamine Section 7. Handling and Storage Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear Precautions suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep container tightly closed. Keep container in a cool, well-ventilated area. Storage Section 8. Exposure Controls/Personal Protection Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below Engineering Controls recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE of a Large Spill handling this product. Exposure LimitsZinc oxide TWA: 5 STEL: 10 (mg/m3) from ACGIH (TLV) [United States] Inhalation TWA: 15 (mg/m3) from OSHA (PEL) [United States] Inhalation Total. TWA: 5 STEL: 10 CEIL: 25 (mg/m3) from NIOSH Inhalation TWA: 5 STEL: 10 (mg/m3) from OSHA (PEL) [United States] Inhalation Respirable. Ferric oxide TWA: 15 (mg/m3) from OSHA (PEL) [United States] Inhalation Total. TWA: 5 (mg/m3) from ACGIH (TLV) [United States] Inhalation Respirable. TWA: 4 (mg/m3) [United Kingdom (UK)] Inhalation Respirable. TWA: 10 (mg/m3) [Canada] Inhalation Total. TWA: 5 (mg/m3) [Canada] Inhalation Respirable. TWA: 10 (mg/m3) [United Kingdom (UK)] Inhalation Total. Consult local authorities for acceptable exposure limits. Section 9. Physical and Chemical Properties Solid. (Powdered solid.)Odorless. Physical state andO dor appearance Not available. Taste Not applicable. Molecular Weight Pink Color Not applicable. pH (1% soln/water) Not available. Boiling Point 1975°C (3587°F) based on data for: Zinc oxide. Melting Point Not available. Critical Temperature The only known value is 5.607 (Water = 1) (Zinc oxide). Specific Gravity Not applicable. Vapor Pressure Not available. Vapor Density Not available. Volatility Not available. Odor Threshold Not available. Water/Oil Dist. Coeff. Not available. Ionicity (in Water) Not available. Dispersion Properties Insoluble in cold water, hot water. Solubility Soluble in dilute acetic acid or mineral acid, ammonia, ammonium carbonate, and fixed alkali hydroxide solution Calamine Section 10. Stability and Reactivity Data The product is stable. Stability Not available. Instability Temperature Conditions of Instability Incompatible materials Incompatibility with various Not available. substances Non-corrosive in presence of glass. Corrosivity Reacts violently with magnesium, linseed oil. Special Remarks on Reacts with hydrochloric acid to produce zinc chloride. Reactivity Reacts with sulfuric acid to produce zinc sulfate. Reacts with hydrogen fluoride to produce zinc fluoride tetrahydrate. Gradually absorbs CO2 on exposure to air. Sublimes at normal pressure. Zinc Oxide reacts with Carbon Monoxide or hydrogen to produce elemental zinc. Not available. Special Remarks on Corrosivity Will not occur. Polymerization Section 11. Toxicological Information Inhalation. Ingestion. Routes of Entry Acute oral toxicity (LD50): 7950 mg/kg [Mouse]. (Zinc oxide). Toxicity to Animals Chronic Effects on Humans CARCINOGENIC EFFECTS: Classified 3 (Not classifiable for human.) by IARC [Ferric oxide]. Contains material which may cause damage to the following organs: lungs, eyes. Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Humans Not available. Special Remarks on Toxicity to Animals Special Remarks onMay cause adverse reproductive effects based on animal data. No human data found at this time. Chronic Effects on Humans May affect genetic material (mutagenic). Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansMay cause mild skin irritation. Eyes: May cause mechanical eye irritation and conjunctivitis. Inhalation: May cause mechanical irritation of the respiratory tract. A few sources claim that finely divided zinc oxide dust can cause "metal fume fever." Zinc oxide dust is generally considered a nuisance dust; adverse effects are unlikely when exposures are kept under reasonable control. Inhalation of high concentrations of Zinc Oxide fume or dust may cause "Metal Fume Fever." Symptoms of metal fume fever may include a flu-like condition involving headache, chills, fever, sweats, nausea, vomiting, cough, muscle aches and pains, and difficulty breathing, ;ulmonary edema. May also affect the liver. Ingestion: May cause digestive tract irritation although Zinc oxide has a low toxicity by oral exposure route. Chronic Potential Health Effects: Ingestion: Prolonged or repeated ingestion of zinc oxide may affect blood, metabolism, and the thyroid. Section 12. Ecological Information Not available. Ecotoxicity Not available. BOD5 and COD Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The product itself and its products of degradation are not toxic. Toxicity of the Products of Biodegradation Calamine Not available. Special Remarks on the Products of Biodegradation Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information Not a DOT controlled material (United States). DO T Cl assi fi cati on Not applicable. Identification Not applicable. Special Provisions for Transport DO T (Pi ctograms) Section 15. Other Regulatory Information and Pictograms California prop. 65: This product contains the following ingredients for which the State of California has found to Federal and State cause birth defects which would require a warning under the statute: No products were found. Regulations California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: No products were found. Illinois toxic substances disclosure to employee act: Zinc oxide; Ferric oxide New York acutely hazardous substances: Ferric oxide Rhode Island RTK hazardous substances: Zinc oxide Pennsylvania RTK: Zinc oxide; Ferric oxide Minnesota: Zinc oxide; Ferric oxide Massachusetts RTK: Zinc oxide; Ferric oxide New Jersey: Zinc oxide California Director's List of Hazardous Substances: Zinc Oxide; Ferric Oxide TSCA 8(b) inventory: Zinc oxide; Ferric oxide SARA 313 toxic chemical notification and release reporting: Zinc oxide 99% (Listed as Zinc and Zinc compounds) California prop. 65: This product contains the following ingredients for which the State of California has found to California cause cancer which would require a warning under the statute: No products were found. Proposition 65 Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. For Zinc Oxide: Other Regulations EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No. 2i5-222-5). Canada: Listed on Canadian Domestic Substance List (DSL). China: Listed on National Inventory. Japan: Listed on National Inventory (ENCS). Korea: Listed on National Inventory (KECI). Philippines: Listed on National Inventory (PICCS). Australia: Listed on AICS. For Calamine: EINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances. Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non- Domestic Substance List (NDSL). China: Listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Listed on National Inventory (PICCS). Australia: Not listed on AICS. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC) Calamine R50/53- Very toxic to aquaticS60- This material and its container must be organisms, may cause long-termdisposed of as hazardous waste. adverse effects in the aquaticS61- Avoid release to the environment. Refer to environment.special instructions/Safety data sheets. Health Hazard HMIS (U.S.A.)1 National Fire Protection 0 Flammability 0 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG(Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xn