30675-13-9

• 常用中文名：4,5,6,7-四氯茚满-1,3-二酮
• 常用英文名：TCID
• CAS号：30675-13-9
• 分子式：C₉H₂Cl₄O₂
• 分子量：283.923
• 相关类别： 生物化工 抑制剂 泛素化抑制剂(Ubiquitin) DUB 抑制剂
• 发布时间：2018-10-16 15:57:30
• 更新时间：2024-01-02 10:48:35
• TCID (4,5,6,7-Tetrachloroindan-1,3-dione) 是一种有效的选择性神经元泛素 C 末端水解酶 (UCH-L3) 抑制剂,IC50 为 0.6 μM。TCID 减少脑干和脊髓原代神经元中的甘氨酸转运蛋白 GlyT2 泛素化。

名称

• 中文名: 4,5,6,7-四氯茚满-1,3-二酮
• 英文名: 4,5,6,7-tetrachloroindene-1,3-dione
• 英文别名: 1H-Indene-1,3(2H)-dione, 4,5,6,7-tetrachloro-; 4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione; Ubiquitin C-Terminal Hydrolase L3 Inhibitor; Ubiquitin Thiolesterase L3 Inhibitor; 4,5,6,7-Tetrachloroindan-1,3-dione; 4,5,6,7-Tetrachlorindan-1,3-dion; 4,5,6,7-Tetrachlorphenyl-1,3-indandion; 4,5,6,7-tetrachloroindane-1,3-dione; UCH-L3 Inhibitor; TCID; Ubiquitin C-Terminal Esterase L3 Inhibitor

物化性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 448.1±45.0 °C at 760 mmHg
• 熔点: 218-220ºC
• 分子式: C₉H₂Cl₄O₂
• 分子量: 283.923
• 闪点: 188.8±29.3 °C
• 精确质量: 281.880890
• PSA: 34.14000
• LogP: 3.94
• 外观性状: 粉末
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.652
• 储存条件: -20℃

生物活性

• 描述: TCID (4,5,6,7-Tetrachloroindan-1,3-dione) 是一种有效的选择性神经元泛素 C 末端水解酶 (UCH-L3) 抑制剂,IC50 为 0.6 μM。TCID 减少脑干和脊髓原代神经元中的甘氨酸转运蛋白 GlyT2 泛素化。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 细胞周期/DNA损伤 >> 去泛素化酶
• 靶点:

  IC50: 0.6 μM (UCH-L3) and 75 μM (UCH-L1)[1]

• 体外研究: TCID(4,5,6,7-四氯吲哚-1,3-二酮；化合物11)以75μM的IC50抑制UCH-L1[1]。TCID(10μM；1,2小时)减少脑干和脊髓原代神经元中甘氨酸转运体GlyT2的泛素化[2]。
• 参考文献:

  [1]. Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cellline. Chem Biol. 2003 Sep;10(9):837-46.

  [2]. de Juan-Sanz J, et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One. 2013;8(3):e58863.

MSDS

Name: 4 5 6 7-Tetrachloroindane-1 3-dione 95+% Material Safety Data Sheet Synonym: CAS: 30675-13-9 Section 1 - Chemical Product MSDS Name:4 5 6 7-Tetrachloroindane-1 3-dione 95+% Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 30675-13-9 4,5,6,7-Tetrachloroindane-1,3-dione 95+% unlisted Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 30675-13-9: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: brown Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 220 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C9H2Cl4O2 Molecular Weight: 284 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, carbon dioxide, acrid smoke and fumes. Hazardous Polymerization: Not available. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 30675-13-9 unlisted. LD50/LC50: Not available. Carcinogenicity: 4,5,6,7-Tetrachloroindane-1,3-dione - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 30675-13-9: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 30675-13-9 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 30675-13-9 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R36/37/38
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2914700090

海关

海关编码	2914700090
中文概述	2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 丙酮报明包装
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%