436-32-8

• 常用中文名：地弗地衣酸
• 常用英文名：Diffractaic acid
• CAS号：436-32-8
• 分子式：C₂₀H₂₂O₇
• 分子量：374.38400
• 相关类别： 信号通路 细胞凋亡 细胞凋亡
• 发布时间：2018-06-17 21:15:40
• 更新时间：2024-01-02 15:41:40
• Diffractaic acid 是 U. longissimi 的主要成分,在各种疾病研究中可作为有效的促凋亡剂。Diffractaic acid 还具有止痛和解热效果。

名称

• 中文名: 地弗地衣酸
• 英文名: 4-(2,4-dimethoxy-3,6-dimethylbenzoyl)oxy-2-hydroxy-3,6-dimethylbenzoic acid
• 英文别名: 2,4-dimethoxy-3,6-dimethylbenzoic acid 4'-carboxy-3'-hydroxy-2',5'-dimethylphenyl ester; diffractic acid; diffractaic acid; Diffractasaeure; Dirbizomic acid; DIFFRACTOIC ACID; Dirhizomic acid; DIFFRACTANIC ACID; diffratic acid

物化性质

• 密度: 1.26g/cm3
• 沸点: 604.9ºC at 760mmHg
• 分子式: C₂₀H₂₂O₇
• 分子量: 374.38400
• 闪点: 214.2ºC
• 精确质量: 374.13700
• PSA: 102.29000
• LogP: 3.56040
• 蒸汽压: 1.74E-15mmHg at 25°C
• 折射率: 1.583
• 储存条件: 2-8℃

生物活性

• 描述: Diffractaic acid 是 U. longissimi 的主要成分,在各种疾病研究中可作为有效的促凋亡剂。Diffractaic acid 还具有止痛和解热效果。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
• 体内研究: 通过醋酸致小鼠扭体法和尾压法,证明了衍射酸具有镇痛作用[2]。
• 参考文献:

  [1]. Fehmi Odabasoglu, et al. Diffractaic acid, a novel proapoptotic agent, induces with olive oil both apoptosis and antioxidative systems in Ti-implanted rabbits. Eur J Pharmacol. 2012 Jan 15;674(2-3):171-8.

  [2]. E Okuyama, et al. Usnic acid and diffractaic acid as analgesic and antipyretic components of Usnea diffracta. Planta Med. 1995 Apr;61(2):113-5.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VH3708850 CHEMICAL NAME : beta-Resorcylic acid, 3,6-dimethyl-, 4-(2,4-dimethoxy-3,6-dimethylbenzoate) CAS REGISTRY NUMBER : 436-32-8 BEILSTEIN REFERENCE NO. : 2915070 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C20-H22-O7 MOLECULAR WEIGHT : 374.42 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 962 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,335,1981

安全

• 海关编码: 2918990090

合成路线

56410-45-8 ~% 436-32-8

文献：Kumar, Sunil; Mueller, Klaus European Journal of Medicinal Chemistry, 1999 , vol. 34, # 12 p. 1035 - 1042

31581-32-5 ~% 436-32-8

文献：Kumar, Sunil; Mueller, Klaus European Journal of Medicinal Chemistry, 1999 , vol. 34, # 12 p. 1035 - 1042

56410-34-5 ~% 436-32-8

文献：Kumar, Sunil; Mueller, Klaus European Journal of Medicinal Chemistry, 1999 , vol. 34, # 12 p. 1035 - 1042

56410-30-1 ~% 436-32-8

文献：Kumar, Sunil; Mueller, Klaus European Journal of Medicinal Chemistry, 1999 , vol. 34, # 12 p. 1035 - 1042

上下游产品

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31581-32-5 56410-30-1
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海关

海关编码	2918990090
中文概述	2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%