5800-19-1

• 常用中文名：甲硫平
• 常用英文名：Metiapine
• CAS号：5800-19-1
• 分子式：C₁₉H₂₁N₃S
• 分子量：323.45500
• 发布时间：2018-02-28 08:00:00
• 更新时间：2024-01-14 13:35:47

名称

• 中文名: 甲硫平
• 英文名: 8-methyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine
• 英文别名: 11-(N-Methylpiperazino)-2-methyldibenzo<b.f>-1,4-thiazepin; 2-methyl-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine; DIBENZO(b,f)(1,4)THIAZEPINE,2-METHYL-11-(4-METHYL-1-PIPERAZINYL); Metiapine; Metiapina; Metiapina [INN-Spanish]; Metiapinum; 3-Methyl-11-(4-methyl-1-piperazinyl)dibenzo<b,f><1,4>thiazepin; Metiapinum [INN-Latin]; 2-Methyl-11-(4-methyl-1-piperazinyl)dibenzo(b,f)(1,4)thiazepine

物化性质

• 密度: 1.22g/cm3
• 沸点: 473.6ºC at 760mmHg
• 分子式: C₁₉H₂₁N₃S
• 分子量: 323.45500
• 闪点: 240.2ºC
• 精确质量: 323.14600
• PSA: 44.14000
• LogP: 3.09670
• 折射率: 1.669

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HQ2275000 CHEMICAL NAME : Dibenzo(b,f)(1,4)thiazepine, 2-methyl-11-(4-methyl-1-piperazinyl)- CAS REGISTRY NUMBER : 5800-19-1 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C19-H21-N3-S MOLECULAR WEIGHT : 323.49 WISWESSER LINE NOTATION : T C676 BS INJ M1 J- AT6N DNTJ D1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 934 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,334,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 487 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,220,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 680 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,334,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,220,1973 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 42 mg/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,212,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 24 mg/kg SEX/DURATION : female 9-16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,212,1973

合成路线

3159-10-2 ~% 5800-19-1

文献：Schmutz,J. et al. Helvetica Chimica Acta, 1967 , vol. 50, p. 245 - 254

109-01-3 13745-90-9 ~% 5800-19-1

文献：Schmutz,J. et al. Helvetica Chimica Acta, 1967 , vol. 50, p. 245 - 254

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