12656-40-5

• 常用中文名：Althiomycin
• 常用英文名：Althiomycin
• CAS号：12656-40-5
• 分子式：C₁₆H₁₇N₅O₆S₂
• 分子量：439.46600
• 发布时间：2016-06-03 10:09:36
• 更新时间：2024-04-05 09:09:00
• Althiomycin, also known as matamycin, is a thiazole antibiotic, effective against Gram-positive and Gram-negative bacteria. Isolated from Streptomyces matensis, Althiomycin was first described by Margalith et al. in 1959. It acts a protein synthesis inhibitor and its site of action is the 50S subunit of the bacterial ribosome.

名称

• 英文名: 4-Thiazolecarboxamide, N-[1-[4-[(2,5-dihydro-4-methoxy-2-oxo-1H-pyrrol-1-yl)carbonyl]-4,5-dihydro-2-thiazolyl]-2-hydroxyethyl]-2-[(hydroxyimino)methyl]
• 英文别名: Matamycin; 116-A; althiomycin

物化性质

• 密度: 1.72g/cm3
• 分子式: C₁₆H₁₇N₅O₆S₂
• 分子量: 439.46600
• 精确质量: 439.06200
• PSA: 207.32000
• 折射率: 1.768

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XJ3500000 CHEMICAL NAME : 4-Thiazolecarboxamide, N-(1-(4-((2,5-dihydro-4-methoxy-2-oxo-1H-pyrrol-1-yl) carbonyl)-4,5- dihydro-2-thiazolyl)-2-hydroxyethyl)-2-((hydroxyimino )methyl)- CAS REGISTRY NUMBER : 12656-40-5 LAST UPDATED : 198211 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C16-H17-N5-O6-S2 MOLECULAR WEIGHT : 439.50 WISWESSER LINE NOTATION : T5N CSJ B1UNQ EVMY1Q- BT5N CSJ EV- AT5NV EHJ DO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 720 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,122,1967