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10085-81-1生产厂家

10085-81-1价格

10085-81-1

10085-81-1结构式
10085-81-1结构式
  • 常用中文名:盐酸苄辛胺
  • 常用英文名:Benzoctamine Hydrochloride
  • CAS号:10085-81-1
  • 分子式:C18H20ClN
  • 分子量:285.81100
  • 相关类别: 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
  • 发布时间:2018-05-14 08:00:00
  • 更新时间:2024-01-10 20:04:47
  • Benzoctamine hydrochloride (Ba-30803) 是一种具有抗焦虑作用的精神活性药物。Benzoctamine hydrochloride阻断中枢突触后 5-羟色胺受体,并可降低脑内5-HT的周转。

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中文名 盐酸苯佐卡因
英文名 Benzoctamine hydrochloride
英文别名 Benzoctamine HCl
Tacitin
Tacitine
EINECS 233-216-0
BA 30,803
描述 Benzoctamine hydrochloride (Ba-30803) 是一种具有抗焦虑作用的精神活性药物。Benzoctamine hydrochloride阻断中枢突触后 5-羟色胺受体,并可降低脑内5-HT的周转。
相关类别
体内研究 苯并辛胺盐酸盐(Ba-30803)抑制L-5-羟色胺(5-HTP)诱导的小鼠头部抽搐反应和5-甲氧基色胺(5-MT)预处理的大鼠头部抽搐反应。苯并辛胺也能拮抗色胺(TRP)诱导的大鼠前爪阵挛性惊厥[2]。
参考文献

[1]. Lippmann W, et al. Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain. Br J Pharmacol. 1974;51(4):571-575.

[2]. Przegaliński E, et al. On the central antiserotonin activity of benzoctamine and opipramol. Pol J Pharmacol Pharm. 1978;30(6):781-790.

沸点 372ºC at 760mmHg
分子式 C18H20ClN
分子量 285.81100
闪点 181.1ºC
精确质量 285.12800
PSA 12.03000
LogP 4.62410
蒸汽压 9.91E-06mmHg at 25°C
储存条件 通风低温干燥

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KJ4550000
CHEMICAL NAME :
9,10-Ethanoanthracene-9-(10H)-methylamine, N-methyl-, hydrochloride
CAS REGISTRY NUMBER :
10085-81-1
LAST UPDATED :
199506
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C18-H19-N.Cl-H
MOLECULAR WEIGHT :
285.84
WISWESSER LINE NOTATION :
L6 H666/GP 2AF P&&TTJ G1M1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
26 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,336,1972 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
51 mg/kg
SEX/DURATION :
female 2-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927- Volume(issue)/page/year: 49,1309,1973