931706-15-9

• 常用中文名：PPQ-102
• 常用英文名：PPQ 102
• CAS号：931706-15-9
• 分子式：C₂₆H₂₂N₄O₃
• 分子量：438.478
• 相关类别： 信号通路 跨膜转运 CFTR
• 发布时间：2017-02-13 08:17:13
• 更新时间：2024-01-02 18:56:59
• PPQ-102是CFTR抑制剂，能抑制CFTR氯流，IC50为90 nM。

名称

• 中文名: PPQ-102
• 英文名: 7,9-Dimethyl-6-(5-methyl-2-furyl)-11-phenyl-6,7-dihydropyrimido[4 ',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione
• 英文别名: 7,9-Dimethyl-6-(5-methyl-2-furyl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione; Pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione, 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-; 7.9-Dimethylxanthin; 7,9-dimethoxy-5H-pyrido<3,2-c>azepine; 7,9-dimethylxanthine; 7,9-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purinium betaine; 7,9-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purinium-betain; 7,9-dimethoxy-5H-pyrido<3,2-c>-azephine; 3,9-dimethylxanthine; PPQ-102

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 648.7±65.0 °C at 760 mmHg
• 分子式: C₂₆H₂₂N₄O₃
• 分子量: 438.478
• 闪点: 346.1±34.3 °C
• 精确质量: 438.169189
• PSA: 74.10000
• LogP: 3.48
• 外观性状: white solid
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.720
• 储存条件: -20℃

生物活性

• 描述: PPQ-102是CFTR抑制剂,能抑制CFTR氯流,IC50为90 nM。
• 相关类别:
  信号通路 >> 跨膜转运 >> CFTR
  研究领域 >> 其他
• 参考文献:

  [1]. Tradtrantip L, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55.

  [2]. Stewart AK, et al. SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization. Am J Physiol Cell Physiol. 2011 Aug;301(2):C289-303.

  [3]. Martin C, et al. CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. Eur Respir J. 2013 Dec;42(6):1553-62.

合成路线

620-02-0 433971-83-6 ~82% 931706-15-9

文献：Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477

626-48-2 ~% 931706-15-9

文献：Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477

13509-52-9 ~% 931706-15-9

文献：Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477

444058-30-4 ~% 931706-15-9

文献：Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477

443667-38-7 ~% 931706-15-9

文献：Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477

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