329932-55-0

329932-55-0结构式

常用中文名：FM19G11
常用英文名：FM19G11
CAS号：329932-55-0
分子式：C₂₃H₁₇N₃O₈
分子量：463.39600
相关类别：信号通路代谢酶/蛋白酶 HIF/HIF脯氨酰-羟化酶
发布时间：2017-07-15 07:18:10
更新时间：2024-01-09 18:39:48
FM19G11 是一种 hypoxia-inducible factor-1-alpha (HIF-1α) 抑制剂,在 HeLa 细胞中抑制缺氧诱导的荧光素酶活性,其 IC50 值为 80 nM。当 HIF-1α 途径在常氧条件下失活时,FM19G11 会调节其他信号途径,包括 mTOR 和 PI3K/Akt/eNOS。

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中文名	3-[(2,4-二硝基苯甲酰基)氨基]-苯甲酸2-(4-甲基苯基)-2-氧乙基酯
英文名	[2-(4-methylphenyl)-2-oxoethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate
英文别名	fm19g11

描述	FM19G11 是一种 hypoxia-inducible factor-1-alpha (HIF-1α) 抑制剂,在 HeLa 细胞中抑制缺氧诱导的荧光素酶活性,其 IC50 值为 80 nM。当 HIF-1α 途径在常氧条件下失活时,FM19G11 会调节其他信号途径,包括 mTOR 和 PI3K/Akt/eNOS。
相关类别	研究领域 >> 癌症信号通路 >> 代谢酶/蛋白酶 >> HIF/HIF脯氨酰-羟化酶研究领域 >> 神经疾病
靶点	HIF-1α[1]
体外研究	FM19G11(30-300nm)抑制HeLa细胞系中的HIFα蛋白[1]。FM19G11(500 n m)促进缺氧条件下少突胶质细胞分化[1]。FM19G11(300 nM；3天)显著抑制缺氧GBM-XD、缺氧T98G和常氧T98G细胞中O6-甲基鸟嘌呤DNA甲基转移酶(MGMT)的mRNA水平[2]。M19G11(300 nM；3天)显著增强替莫唑胺(TMZ)的促凋亡作用,尽管FM19G11本身并不诱导凋亡[2]。细胞活力测定[2]细胞系：GBM-XD和T98G细胞浓度：300 nM孵育时间：3天结果：低氧培养中两种细胞株MGMT表达均显著抑制。正常氧培养的98G细胞中MGMT表达下调。细胞活力测定[2]细胞系：GBM-XD和T98G细胞浓度：300nm孵育时间：3天结果：自身无细胞毒性。增强TMZ对缺氧GBM-XD细胞、缺氧T98G细胞和常氧T98G细胞的细胞毒性。
体内研究	FM19G11(髓内注射；1-8周)改善严重脊髓损伤(SCI)的运动能力[3]。FM19G11(髓内注射；8周)诱导GAP43(轴突生长标记物)和RIP(损伤处有髓少突胶质细胞标记物)的表达[3]。
参考文献	[1]. Victoria MM, et, al. FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J Biol Chem. 2010 Jan 8; 285(2): 1333-42. [2]. You CG, et, al. FM19G11 inhibits O 6 -methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. Cancer Med. 2018 May 15; 7(7): 3292-3300. [3]. Ana AA, et, al. FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury. Int J Mol Sci. 2018 Jan 9; 19(1): 200.

分子式	C₂₃H₁₇N₃O₈
分子量	463.39600
精确质量	463.10200
PSA	167.60000
LogP	5.53380
外观性状	powder，off-white to light brown
储存条件	2-8°C

SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name: FM19G11
REACH No.: A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later

registration deadline.
CAS-No.: 329932-55-0
Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Manufacture of substances

SECTION 2: Hazards identification
Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogramnone
Signal wordnone
Hazard statement(s)none
Precautionary statement(s) none
Supplemental Hazardnone
Statements
The following percentage of the mixture consists of ingredient(s) with unknown acute toxicity:
The following percentage of the mixture consists of ingredient(s) with unknown hazards to the aquatic
environment:
Other hazards - none

SECTION 3: Composition/information on ingredients
Substances
Synonyms: 3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl
ester
[2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate
Formula: C23H17N3O8
Molecular Weight: 463,4 g/mol
CAS-No.: 329932-55-0
No components need to be disclosed according to the applicable regulations.

SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Avoid
breathing dust.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage
Precautions for safe handling
Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: 2 - 8 °C
Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards
such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Choose body protection in relation to its type, to the concentration and amount of dangerous
substances, and to the specific work-place., The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection is not required. Where protection from nuisance levels of dusts are desired,
use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.

SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) AppearanceForm: solid
b) Odourno data available
c) Odour Thresholdno data available
d) pHno data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash pointno data available
h) Evapouration rateno data available
i) Flammability (solid, gas) no data available
j) Upper/lowerno data available
flammability or
explosive limits
k) Vapour pressureno data available
l) Vapour densityno data available
m) Relative densityno data available
n) Water solubilityno data available
o) Partition coefficient: n- log Pow: 3,431
octanol/water
p) Auto-ignitionno data available
temperature
q) Decompositionno data available
temperature
r) Viscosityno data available
s) Explosive propertiesno data available
t) Oxidizing propertiesno data available
Other safety information
no data available

SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC:No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: Not available
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.

SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information
UN number
ADR/RID: -IMDG: -IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA:Not dangerous goods
Transport hazard class(es)
ADR/RID: -IMDG: -IATA: -
Packaging group
ADR/RID: -IMDG: -IATA: -
Environmental hazards
ADR/RID: noIMDG Marine pollutant: noIATA: no
Special precautions for user
no data available

SECTION 15 - REGULATORY INFORMATION
N/A

SECTION 16 - ADDITIONAL INFORMATION
N/A

危险品运输编码	NONH for all modes of transport

906131-02-0

619-41-0

~52%

329932-55-0

文献：Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe; Instituto de Salud Carlos III; Universidad de Valencia Patent: EP2292587 A1, 2011 ; Location in patent: Page/Page column 16 ;

99-05-8

329932-55-0

文献：Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe; Instituto de Salud Carlos III; Universidad de Valencia Patent: EP2292587 A1, 2011 ;

4518-10-9

329932-55-0

文献：Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe; Instituto de Salud Carlos III; Universidad de Valencia Patent: EP2292587 A1, 2011 ;

348600-05-5

329932-55-0

文献：Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe; Instituto de Salud Carlos III; Universidad de Valencia Patent: EP2292587 A1, 2011 ;

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