18472-51-0

• 常用中文名：葡萄糖酸氯己定
• 常用英文名：Chlorhexidine digluconate
• CAS号：18472-51-0
• 分子式：C₃₄H₅₄Cl₂N₁₀O₁₄
• 分子量：897.757
• 相关类别： 原料药 人工合成抗感染类药 消毒防腐药
• 发布时间：2018-02-07 08:00:00
• 更新时间：2024-01-02 20:34:03
• Chlorhexidine双葡萄糖酸盐是抗菌剂,对革兰氏阴性和阳性菌有效。

名称

• 中文名: 葡萄糖酸氯己定
• 英文名: chlorhexidine gluconate
• 中文别名: 氯己定二葡糖酸盐; 伞花醇; 二葡糖酸氯己定; 1,1'-六亚甲基双[5-(4-氯苯基)双胍]二葡糖酸盐; 1,6-双(N1-对氯苯基-N5-双胍基)己烷二葡萄糖酸盐
• 英文别名: Maskin; Unisept; Chlorhexamed; 1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane; Septeal; (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid - N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] (2:1); Betasept; N,N''''-1,6-Hexanediylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2); N,N''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide di-D-gluconate; Peridex; Rotersept; hibitane; Manusan; chlorohexidine digluconate; Chlorhexidin Bigluconate; N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2); MFCD00083599; Chlorhexidine gluconate; disteryl; chlorhexidine gigluconate; D-Gluconic Acid compd. with N,N''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1); Hibident; Plurexid; Hibidil; N,N''''-Hexane-1,6-diylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2); 1,1'-Hexamethylenebis(5-[p-chlorophenyl]biguanide); chlorhexidine bigluconate; EINECS 242-354-0; STERILON; 4-CHLORHEXIDINE DIGLUCONATE; Imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(4-chlorophenyl)-, compd. with D-gluconic acid (1:2); Corsodyl; UNII-MOR84MUD8E; chlorhexidine D-digluconate; chlorhexidine di-D-gluconate; Hibiscrub; Maskin R; Hibisol; 1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] Digluconate; Hexidine; 1,1‘-Hexamethylenebis(5-[p-chlorophenyl]biguanide); pHiso-Med; orahexal; placout; Chlorhexidine digluconate; abacil; Chlorhexidine (digluconate)

物化性质

• 密度: 1.06 g/mL at 25 °C(lit.)
• 沸点: 699.3ºC at 760 mmHg
• 熔点: 134ºC
• 分子式: C₃₄H₅₄Cl₂N₁₀O₁₄
• 分子量: 897.757
• 闪点: 376.7ºC
• 精确质量: 896.319824
• PSA: 444.48000
• 外观性状: 无色至淡黄色透明液体
• 蒸汽压: 0mmHg at 25°C
• 储存条件:

  常温密闭避光，通风干燥

• 稳定性:

  常温常压下稳定

  避免的物料： 水溶液与碱金属碱土金属和许多有机无机的活性化学药品是不相溶的

• 计算化学:

  1、 氢键供体数量：18

  2、 氢键受体数量：24

  3、 可旋转化学键数量：23

  4、 互变异构体数量：36

  5、 拓扑分子极性表面积（TPSA）：455

  6、 重原子数量：60

  7、 表面电荷：0

  8、 复杂度：819

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：8

  11、 不确定原子立构中心数量：0

  12、 确定化学键立构中心数量：2

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：3

• 更多:

  1. 性状：外观无色或淡黄色几乎透明略为黏稠的液体；无臭或几乎无臭

  2. 密度（g/mL,25/4℃）：1.06(lit.)

  3. 相对蒸汽密度（g/mL,空气=1）：不确定

  4. 熔点（ºC）：不确定

  5. 沸点（ºC,常压）：不确定

  6. 沸点（ºC, 5.2kPa）：不确定

  7. 折射率：不确定

  8. 闪点（ºC）：不确定

  9. 比旋光度（º）：不确定

  10. 自燃点或引燃温度（ºC）：不确定

  11. 蒸气压（kPa,25ºC）：不确定

  12. 饱和蒸气压（kPa,60ºC）：不确定

  13. 燃烧热（KJ/mol）：不确定

  14. 临界温度（ºC）：不确定

  15. 临界压力（KPa）：不确定

  16. 油水（辛醇/水）分配系数的对数值：不确定

  17. 爆炸上限（%,V/V）：不确定

  18. 爆炸下限（%,V/V）：不确定

  19. 溶解性：不确定

生物活性

• 描述: Chlorhexidine双葡萄糖酸盐是抗菌剂,对革兰氏阴性和阳性菌有效。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Jenkins, S., M. Addy, and W. Wade, The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts in vivo. J Clin Periodontol, 1988. 15(7): p. 415-24.

  [2]. Maki, D.G., M. Ringer, and C.J. Alvarado, Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet, 1991. 338(8763): p. 339-43.

MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking Product identifiers Product name: Chlorhexidine digluconate solution REACH No.: A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline. Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances SECTION 2: Hazards identification Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 2), H411 For the full text of the H-Statements mentioned in this Section, see Section 16. Classification according to EU Directives 67/548/EEC or 1999/45/EC N Dangerous for theR50/53 environment For the full text of the R-phrases mentioned in this Section, see Section 16. Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal wordWarning Hazard statement(s) H400Very toxic to aquatic life. H411Toxic to aquatic life with long lasting effects. Precautionary statement(s) P273Avoid release to the environment. Supplemental Hazardnone Statements According to European Directive 67/548/EEC as amended. Hazard symbol(s)N Dangerous for the environment R-phrase(s) R50/53Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. S-phrase(s) S61Avoid release to the environment. Refer to special instructions/ Safety data sheets. Other hazards - none SECTION 3: Composition/information on ingredients Mixtures Hazardous ingredients according to Regulation (EC) No 1272/2008 ComponentClassificationConcentration D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13- tetraazatetradecanediamidine (2:1) CAS-No.18472-51-0Acute Tox. 4; Aquatic Acute 1;20 - 25 % EC-No.242-354-0Aquatic Chronic 1; H302, H410 Hazardous ingredients according to Directive 1999/45/EC ComponentClassificationConcentration D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13- tetraazatetradecanediamidine (2:1) CAS-No.18472-51-0Xn, N, R22R50/5320 - 25 % EC-No.242-354-0 For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16 SECTION 4: First aid measures Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 Indication of any immediate medical attention and special treatment needed no data available SECTION 5: Firefighting measures Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available SECTION 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. For personal protection see section 8. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. SECTION 7: Handling and storage Precautions for safe handling For precautions see section 2.2. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8 °C Light sensitive. Specific end use(s) A part from the uses mentioned in section 1.2 no other specific uses are stipulated SECTION 8: Exposure controls/personal protection Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK (EU EN 14387) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. SECTION 9: Physical and chemical properties Information on basic physical and chemical properties a) AppearanceForm: liquid b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingno data available point f) Initial boiling point and no data available boiling range g) Flash pointno data available h) Evaporation rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative density1,06 g/cm3 at 25 °C n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Auto-ignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available SECTION 10: Stability and reactivity Reactivity no data available Chemical stability Stable under recommended storage conditions. Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Strong oxidizing agents Hazardous decomposition products Other decomposition products - no data available In the event of fire: see section 5 SECTION 11: Toxicological information Information on toxicological effects Acute toxicity no data available Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity no data available Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. SECTION 12: Ecological information Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted Other adverse effects Very toxic to aquatic life. SECTION 13: Disposal considerations Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. SECTION 14: Transport information UN number ADR/RID: 3082IMDG: 3082IATA: 3082 UN proper shipping name ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13- tetraazatetradecanediamidine (2:1)) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13- tetraazatetradecanediamidine (2:1)) IATA:Environmentally hazardous substance, liquid, n.o.s. (D-Gluconic acid, compound with N,N''- bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)) Transport hazard class(es) ADR/RID: 9IMDG: 9IATA: 9 Packaging group ADR/RID: IIIIMDG: IIIIATA: III Environmental hazards ADR/RID: yesIMDG Marine Pollutant: yesIATA: yes Special precautions for user Further information EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids. SECTION 15: Regulatory information This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment For this product a chemical safety assessment was not carried out SECTION 16: Other information Full text of H-Statements referred to under sections 2 and 3. Acute Tox.Acute toxicity Aquatic AcuteAcute aquatic toxicity Aquatic ChronicChronic aquatic toxicity H302Harmful if swallowed. H400Very toxic to aquatic life. H410Very toxic to aquatic life with long lasting effects. H411Toxic to aquatic life with long lasting effects. Full text of R-phrases referred to under sections 2 and 3 NDangerous for the environment R22Harmful if swallowed. R50/53Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. XnHarmful Further information Copyright 2013 Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

毒性和生态

毒理学数据: 急性毒性：大鼠口经LD50： 2 mg/kg；大鼠皮下注射LD50： 3320 mg/kg；大鼠静脉LD50： 24200 ug/kg；小鼠口经LD50： 1260 mg/kg；小鼠皮下注射LD50： 1140 mg/kg；小鼠静脉LD50： 12900 ug/kg 致突变：杆菌subtilis DNA repairTEST系统：1mg/L 生态学数据: 通常对水体是稍微有害的，不要将未稀释或大量产品接触地下水，水道或污水系统，未经政府许可勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : DU1950000 CAS REGISTRY NUMBER : 18472-51-0 LAST UPDATED : 199706 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C22-H30-Cl2-N10.2C6-H12-O7 MOLECULAR WEIGHT : 897.88 WISWESSER LINE NOTATION : GR DMYUM&MYUM&M6MYUM&MYUM&MR DG &QVYQYQYQYQ1Q 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 24200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1260 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1140 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 12900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 1 mg/L REFERENCE : ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953- Volume(issue)/page/year: 32,171,1986 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3093 No. of Facilities: 4592 (estimated) No. of Industries: 5 No. of Occupations: 36 No. of Employees: 643404 (estimated) No. of Female Employees: 561783 (estimated)

安全

• 符号: GHS09
• 信号词: Warning
• 危害声明: H410
• 警示性声明: P273-P501
• 个人防护装备: Eyeshields;Faceshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
• 危害码 (欧洲): N
• 风险声明 (欧洲): 50/53
• 安全声明 (欧洲): 61
• 危险品运输编码: UN 3082 9 / PGIII
• WGK德国: -
• 海关编码: 3004909090

海关

海关编码	3004909090