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37517-30-9

37517-30-9结构式
37517-30-9结构式
  • 常用中文名：醋丁洛尔
  • 常用英文名：acebutolol
  • CAS号：37517-30-9
  • 分子式：C18H28N2O4
  • 分子量：336.426
  • 相关类别： 原料药 循环系统用药 抗心律失常药
  • 发布时间：2018-08-12 18:51:31
  • 更新时间：2024-01-02 14:20:32
  • 醋丁洛尔是一种口服活性β1肾上腺素能受体(β1AR)拮抗剂。醋丁洛尔用于高血压、心绞痛和心律失常的研究[1][2][3]。

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中文名 醋丁洛尔
英文名 acebutolol
中文别名 醋丁酰心安
N-[3-乙酰基-4-(2-羟基-3-异丙基氨基丙氧基)苯基]丁酰胺
英文别名 3'-Acetyl-4'-[2-hydroxy-3-(isopropylamino)propoxy]butyranilide
Butanamide, N-(3-acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-, (±)-
アセブトロール
EINECS 253-539-0
Butanamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-
N-{3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}butanamide
N-{3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}butanamide
acebutolol
N-(3-Acetyl-4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)butyramide
IL 17803A
MFCD00599435
Acecor
描述 醋丁洛尔是一种口服活性β1肾上腺素能受体(β1AR)拮抗剂。醋丁洛尔用于高血压、心绞痛和心律失常的研究[1][2][3]。
相关类别
靶点

β1 adrenoceptor

体内研究 醋丁洛尔是一种β受体阻滞剂,用于治疗高血压和心律失常。大鼠单次静脉注射(10 mg/kg)醋丁洛尔后,血浆清除率为61.9 mL/min/kg,分布体积为9.6 L/kg,消除半衰期为1.8小时。大鼠单次静脉注射(50 mg/kg)醋丁洛尔后,血浆清除率为46.5 mL/min/kg,分布体积为9.5 L/kg,消除半衰期为2.3小时[1]。在Sprague-Dawley大鼠中,测得1分钟和10分钟后,乙酰丁洛尔(30 mg/kg)的心输出量分别减少65%和31%。与Sprague-Dawley大鼠的基线值相比,在测量1分钟或10分钟后,醋丁洛尔(30 mg/kg)显著减少大多数器官的局部血流量(RBF)[3]。
参考文献

[1]. Piquette-Miller, M. and F. Jamali, Pharmacokinetics and multiple peaking of acebutolol enantiomers in rats. Biopharm Drug Dispos, 1997. 18(6): p. 543-56.

[2]. Bristow MR, et al. Treatment of chronic heart failure with β-adrenergic receptor antagonists: a convergence of receptor pharmacology and clinical cardiology. Circ Res. 2011 Oct 28;109(10):1176-94.

[3]. Mostafavi, S., R. Lewanczuk, and R. Foster, Influence of acebutolol and metoprolol on cardiac output and regional blood flow in rats. Biopharm Drug Dispos, 2000. 21(4): p. 121-8.
密度 1.1±0.1 g/cm3
沸点 564.1±50.0 °C at 760 mmHg
熔点 119-123ºC
分子式 C18H28N2O4
分子量 336.426
闪点 295.0±30.1 °C
精确质量 336.204895
PSA 87.66000
LogP 1.95
外观性状 晶体
蒸汽压 0.0±1.6 mmHg at 25°C
折射率 1.543
储存条件 库房通风低温干燥
水溶解性 259 mg/L

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EJ3500500
CHEMICAL NAME :
Butanamide, N-(3-acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)prop oxy)phenyl)-, (+-)-
CAS REGISTRY NUMBER :
37517-30-9
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C18-H28-N2-O4
MOLECULAR WEIGHT :
336.48
WISWESSER LINE NOTATION :
3VMR CV1 DO1YQ1MY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
152 mg/kg
TOXIC EFFECTS :
Cardiac - change in conduction velocity Vascular - BP lowering not characterized in autonomic section
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 20,69,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
137 mg/kg/24D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 111,533,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
109 mg/kg/22D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 111,533,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 42,82,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPMDAD Nouvelle Presse Medicale. (Paris, France) V.1-11, 1972-82. Volume(issue)/page/year: 7,3258,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
4 mg/kg
TOXIC EFFECTS :
Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Kidney, Ureter, Bladder - changes in blood vessels or in circulation of kidney
REFERENCE :
MASODV Masui to Sosei. Anesthesia and Resuscitation. (Hiroshima Masui Igakkai, Hiroshima Daigaku Igakubu Masuigaku Kyoshitsu, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, Japan) V.6- 1970- Volume(issue)/page/year: 16,13,1980 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
120 mg/kg
SEX/DURATION :
female 34-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 4(Suppl 1),109,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
1080 mg/kg
SEX/DURATION :
female 1-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 283,1077,1981

海关编码 2924299090
【方法一】
由5'-丁酰胺-2'-(2,3-环氧丙氧)乙酰苯、异丙胺反应制得。
海关编码 2924299090
中文概述 2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 包装
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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