167221-71-8

• 常用中文名：丁酸氯维地平
• 常用英文名：Clevidipine
• CAS号：167221-71-8
• 分子式：C₂₁H₂₃Cl₂NO₆
• 分子量：456.316
• 相关类别： 原料药 循环系统用药 抗高血压病药
• 发布时间：2018-09-09 11:25:59
• 更新时间：2024-01-02 08:31:19
• Clevidipine 是短效二氢吡啶钙离子通道拮抗剂,IC50为7.1 nM。

名称

• 中文名: 4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-3,5-吡啶二甲酸甲基(1-丁酰氧基)甲酯
• 英文名: 5-O-(butanoyloxymethyl) 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• 中文别名: 氯维地平; 丁酸氯维地平; 氯维地平丁酸酯/丁酸氯维地平
• 英文别名: (butanoyloxy)methyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; Cleviprex; clevidipine; (±)-Hydroxymethyl Methyl 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate Butyrate (Ester); Methyl (1-oxobutoxy)methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate; Clevidipine butyrate; Clevidipine,Cleviprex; H 324/38; (Butyryloxy)methyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate; Clevelox; 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl (1-oxobutoxy)methyl ester; rac-Clevidipine

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 539.7±50.0 °C at 760 mmHg
• 熔点: 128-130°C
• 分子式: C₂₁H₂₃Cl₂NO₆
• 分子量: 456.316
• 闪点: 280.2±30.1 °C
• 精确质量: 455.090240
• PSA: 90.93000
• LogP: 5.46
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.543
• 储存条件: Refrigerator

生物活性

• 描述: Clevidipine 是短效二氢吡啶钙离子通道拮抗剂,IC50为7.1 nM。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Yi X, Vivien B, Lynch C 3rd. Clevidipine blockade of L-type Ca2+ currents: steady-state and kinetic electrophysiological studies in guinea pigventricular myocytes.

  [2]. Huraux C, Makita T, Szlam F, The vasodilator effects of clevidipine on human internal mammary artery. Anesth Analg. 1997 Nov;85(5):1000-4.

  [3]. Ericsson H, et al. In vitro hydrolysis rate and protein binding of clevidipine, a new ultrashort-acting calcium antagonist metabolised by esterases, in different animal species and man. Eur J Pharm Sci. 1999 Apr;8(1):29-37.

  [4]. Ericsson H, et al. Pharmacokinetics of new calcium channel antagonist clevidipine in the rat, rabbit, and dog and pharmacokinetic/pharmacodynamic relationship in anesthetized dogs. Drug Metab Dispos. 1999 May;27(5):558-64.

  [5]. Schwieler JH, et al. Circulatory effects and pharmacology of clevidipine, a novel ultra short acting and vascular selective calcium antagonist, in hypertensive humans. J Cardiovasc Pharmacol. 1999 Aug;34(2):268-74.

安全

• 危害码 (欧洲): Xi
• 安全声明 (欧洲): 24/25