105184-37-0

• 常用中文名：醋酸脾脏五肽
• 常用英文名：Splenopentin diacetate
• CAS号：105184-37-0
• 分子式：C₃₃H₅₅N₉O₁₁
• 分子量：753.84300
• 相关类别： 生物化工 氨基酸及其衍生物 酪氨酸类衍生物
• 发布时间：2018-04-03 08:00:00
• 更新时间：2024-01-08 12:59:30
• Splenopentin diacetate 是一种合成的免疫调节性五肽,对应于脾脏激素脾脏蛋白的残基 32-36。Splenopentin diacetate 可影响早期的 T 细胞和 B 细胞分化,从而增加 γ 射线照射后小鼠体内抗体形成细胞的数量。

名称

• 中文名: 醋酸脾脏五肽
• 英文名: Splenopentin Acetate
• 中文别名: L-精氨酰-L-赖氨酰-L-ALPHA-谷氨酰-L-缬氨酰-L-酪氨酸二醋酸盐; 脾脏五肽
• 英文别名: SP-5 ACETATE SALT; SPLENOPENTIN ACETATE SALT; ARG-LYS-GLU-VAL-TYR ACETATE; Splenopentin diacetate; SPLENIN FRAGMENT 32-36 ACETATE SALT; SP-5,Splenin Fragment 32-36,Splenopentin; ARG-LYS-GLU-VAL-TYR ACETATE SALT

物化性质

• 分子式: C₃₃H₅₅N₉O₁₁
• 分子量: 753.84300
• 精确质量: 753.40200
• PSA: 362.47000
• LogP: 2.44490
• 储存条件: −20°C
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:13

  3.氢键受体数量:16

  4.可旋转化学键数量:23

  5.互变异构体数量:64

  6.拓扑分子极性表面积:402

  7.重原子数量:57

  8.表面电荷:0

  9.复杂度:1160

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:5

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:3

生物活性

• 描述: Splenopentin diacetate 是一种合成的免疫调节性五肽,对应于脾脏激素脾脏蛋白的残基 32-36。Splenopentin diacetate 可影响早期的 T 细胞和 B 细胞分化,从而增加 γ 射线照射后小鼠体内抗体形成细胞的数量。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: 脾开放素(1-100μM) 增强人类NK细胞,无细胞毒性[2]。脾五肽(0.1 ng/mL-10μg/mL；3 h)诱导T细胞和B细胞前体细胞的表型分化[3]。
• 体内研究: 脾五肽(1mg/kg；i、 p.每周3次,持续7-90天)加速朗格汉斯细胞的募集,并导致小鼠皮肤中朗格汉斯细胞(LC)密度的预处理水平[4]。脾开放素(0.01-100μg/只小鼠；i、 p.)对小鼠的神经肌肉传递没有明显的影响[3]。动物模型：雌性Balb/c/Bln小鼠连续注射环磷酰胺或地塞米松5天[4]剂量：1mg/kg给药：每周3次,连续7-90天。结果：环磷酰胺治疗开始后28天,表皮LCs达到正常数量。地塞米松治疗70天后皮肤LC密度达到正常值。
• 参考文献:

  [1]. Singh VK, et, al. Thymopentin and splenopentin as immunomodulators. Current status. Immunol Res. 1998;17(3):345-68.

  [2]. Rastogi A, et, al. Augmentation of human natural killer cells by splenopentin analogs. FEBS Lett. 1993 Feb 8;317(1-2):93-5.

  [3]. Audhya T, et, al. Contrasting biological activities of thymopoietin and splenin, two closely related polypeptide products of thymus and spleen. Proc Natl Acad Sci U S A. 1984 May;81(9):2847-9.

  [4]. Gruner S, et, al. Stimulation of the recruitment of epidermal Langerhans cells by splenopentin. Arch Dermatol Res. 1990;281(8):526-9.

MSDS

Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE Product identifiers Product name: Arg-Lys-Glu-Val-Tyr acetate salt CAS-No.: 105184-37-0 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances Section2. HAZARDS IDENTIFICATION Classification of the substance or mixture Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008. This substance is not classified as dangerous according to Directive 67/548/EEC. Label elements The product does not need to be labelled in accordance with EC directives or respective national laws. Other hazards - none Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substances Synonyms: SP-5 Splenopentin Splenin Fragment 32-36 Formula: C31H51N9O9 Molecular Weight: 693,79 g/mol Section4. FIRST AID MEASURES Description of first aid measures If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. In case of skin contact Wash off with soap and plenty of water. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Most important symptoms and effects, both acute and delayed To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Indication of any immediate medical attention and special treatment needed no data available Section5. FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx) Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available Section6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Avoid dust formation. Avoid breathing vapors, mist or gas. Environmental precautions Do not let product enter drains. Methods and materials for containment and cleaning up Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. Section7. HANDLING AND STORAGE Precautions for safe handling Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20 °C Specific end uses no data available Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls General industrial hygiene practice. Personal protective equipment Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Section9. PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) AppearanceForm: solid b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingno data available point f) Initial boiling point and no data available boiling range g) Flash pointno data available h) Evaporation rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative densityno data available n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Autoignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available Section10. STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Strong acids, Strong bases Hazardous decomposition products Other decomposition products - no data available Section11. TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity no data available Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity no data available Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects InhalationMay be harmful if inhaled. May cause respiratory tract irritation. IngestionMay be harmful if swallowed. SkinMay be harmful if absorbed through skin. May cause skin irritation. EyesMay cause eye irritation. Signs and Symptoms of Exposure To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Additional Information RTECS: Not available Section12. ECOLOGICAL INFORMATION Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects no data available Section13. DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. Section14. TRANSPORT INFORMATION UN number ADR/RID: -IMDG: -IATA: - UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA:Not dangerous goods Transport hazard class(es) ADR/RID: -IMDG: -IATA: - Packaging group ADR/RID: -IMDG: -IATA: - Environmental hazards ADR/RID: noIMDG Marine pollutant: noIATA: no Special precautions for user no data available Section15. REGULATORY INFORMATION This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment no data available Section16. OTHER INFORMATION Further information Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

安全

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