54663-47-7

• 常用中文名：替贝碘胺
• 常用英文名：Tibezonium iodide
• CAS号：54663-47-7
• 分子式：C₂₈H₃₂IN₃S₂
• 分子量：601.60800
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-08-01 09:50:24
• 更新时间：2024-01-09 18:37:37
• 碘化替苯唑铵是一种口咽消毒剂,具有预防口腔感染的抗菌活性[1]。

名称

• 中文名: 替贝碘胺
• 英文名: Diethylmethyl[2-[[4-[p-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethyl]ammonium iodide
• 中文别名: TIBEZONIUM 碘化物
• 英文别名: tibezonium iodide; tibenzonium iodide; Antoral; Ethanaminium,N,N-diethyl-N-methyl-2-[[4-[4-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]-,iodide; Tibezonium; N,N-Diethyl-N-methyl-2-[[4-[4-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethanaminium iodide; Rec 15-0691; Thiabenzazonium; 2-(Methyl-diaethylammonium-aethylthio)-4-(p-phenyl-thio-phenyl)-3H-1,5-benzodiazepin-jodid; Tibezonium-jodid

物化性质

• 熔点: 162ºC
• 分子式: C₂₈H₃₂IN₃S₂
• 分子量: 601.60800
• 精确质量: 601.10800
• PSA: 75.32000
• LogP: 3.48710

生物活性

• 描述: 碘化替苯唑铵是一种口咽消毒剂,具有预防口腔感染的抗菌活性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 碘化泰菌(5-10μg/mL；15-30分钟)对革兰氏阳性菌显示出良好的抑菌和杀菌活性,尤其是对金黄色葡萄球菌和人化脓性葡萄球菌具有最小抑制浓度(MIC)值≤1微克/毫升[3]。碘化泰(0.25-5μg/mL；30分钟)对金黄色葡萄球菌和化脓性葡萄球菌821的杀菌活性增强,而pH值从6.5-7.0上升到8.0-8.5[3]。
• 参考文献:

  [1]. M Veronese, et al. Mutagenicity studies on tibezonium, a new oropharyngeal disinfectant. Arzneimittelforschung. 1983;33(3):369-72.

  [2]. M Calzavara, et al. [Clinico-experimental study of a new antibactorial agent for local use in stomatology]. Minerva Stomatol. Apr-Jun 1976;25(2):55-66.

  [3]. Veronese M, et al. Antimicrobial activity of tibezonium (TBZ). Chemotherapy. 1977. 23(2):90-7.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KH2770000 CHEMICAL NAME : Ethanaminium, N,N-diethyl-N-methyl-2-((4-(4-(phenylthio)phenyl)- 3H-1,5-benzodiazepin-2-yl) thio)-, iodide CAS REGISTRY NUMBER : 54663-47-7 LAST UPDATED : 199206 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C28-H32-N3-S2.I MOLECULAR WEIGHT : 601.65 WISWESSER LINE NOTATION : T67 GN KN IHJ HS2K2&2&2 JR DSR &I HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,440,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 35 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,152,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,440,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,440,1975