CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
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QC8750000
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CHEMICAL NAME :
-
Morphinan-3,6-alpha-diol, 7,8-didehydro-4, 5-alpha-epoxy-17-methyl-, sulfate
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CAS REGISTRY NUMBER :
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64-31-3
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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56
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MOLECULAR FORMULA :
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C34-H38-N2-O6.H2-O4-S
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MOLECULAR WEIGHT :
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668.82
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WISWESSER LINE NOTATION :
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T B6566 B6/CO 4ABBC R BX HO PN DU GHT&&TTJ FQ JQ P& 2WSQQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - woman
-
DOSE/DURATION :
-
8 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - analgesia
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - man
-
DOSE/DURATION :
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12 mg/kg/4W-I
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
461 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
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235 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - convulsions or effect on seizure threshold
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
108 mg/kg
-
TOXIC EFFECTS :
-
Endocrine - other changes
-
TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
70 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Intramuscular
-
SPECIES OBSERVED :
-
Rodent - rat
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DOSE/DURATION :
-
78 mg/kg
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TOXIC EFFECTS :
-
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
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600 mg/kg
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TOXIC EFFECTS :
-
Behavioral - analgesia
-
TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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275 mg/kg
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TOXIC EFFECTS :
-
Behavioral - analgesia
-
TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
-
180 mg/kg
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TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
156 mg/kg
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TOXIC EFFECTS :
-
Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Intramuscular
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SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
334 mg/kg
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TOXIC EFFECTS :
-
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intracerebral
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
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5100 ug/kg
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TOXIC EFFECTS :
-
Behavioral - convulsions or effect on seizure threshold
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
-
SPECIES OBSERVED :
-
Mammal - dog
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DOSE/DURATION :
-
316 mg/kg
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TOXIC EFFECTS :
-
Behavioral - analgesia Behavioral - sleep
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - guinea pig
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DOSE/DURATION :
-
1 gm/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
-
Rodent - guinea pig
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DOSE/DURATION :
-
391 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
SPECIES OBSERVED :
-
Rodent - guinea pig
-
DOSE/DURATION :
-
400 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - hamster
-
DOSE/DURATION :
-
1250 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Bird - pigeon
-
DOSE/DURATION :
-
321 mg/kg
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TOXIC EFFECTS :
-
Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Bird - chicken
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DOSE/DURATION :
-
125 mg/kg
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TOXIC EFFECTS :
-
Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold Behavioral - somnolence (general depressed activity)
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Bird - duck
-
DOSE/DURATION :
-
213 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Amphibian - frog
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DOSE/DURATION :
-
677 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
-
Amphibian - frog
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DOSE/DURATION :
-
678 mg/kg
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TOXIC EFFECTS :
-
Behavioral - ataxia Behavioral - changes in psychophysiological tests
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
3100 mg/kg/18W-C
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TOXIC EFFECTS :
-
Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
60 gm/kg/14W-C
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TOXIC EFFECTS :
-
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Related to Chronic Data - death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
3150 mg/kg/9W-I
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TOXIC EFFECTS :
-
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in prostate weight
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
430 mg/kg/14W-I
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TOXIC EFFECTS :
-
Blood - hemorrhage Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
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Oral
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DOSE :
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22 mg/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
140 mg/kg
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SEX/DURATION :
-
female 9-22 day(s) after conception
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TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - behavioral
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
50 mg/kg
-
SEX/DURATION :
-
female 1 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Maternal Effects - ovaries, fallopian tubes
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
592 mg/kg
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SEX/DURATION :
-
female 5 day(s) pre-mating female 1-22 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
1420 mg/kg
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SEX/DURATION :
-
female 5 day(s) pre-mating - 21 day(s) post-birth
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TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
1420 mg/kg
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SEX/DURATION :
-
female 5 day(s) pre-mating - 21 day(s) post-birth
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TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - Central Nervous System
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
50 mg/kg
-
SEX/DURATION :
-
female 1 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Fertility - other measures of fertility
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
1400 mg/kg
-
SEX/DURATION :
-
male 28 day(s) pre-mating
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TOXIC EFFECTS :
-
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
141 mg/kg
-
SEX/DURATION :
-
female 7-9 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
187 mg/kg
-
SEX/DURATION :
-
female 17-20 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - other postnatal measures or effects
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
187 mg/kg
-
SEX/DURATION :
-
female 17-20 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - behavioral
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
450 mg/kg
-
SEX/DURATION :
-
female 7 day(s) pre-mating female 3-16 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
DOSE :
-
20 mg/kg
-
SEX/DURATION :
-
female 21 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
2800 mg/kg
-
SEX/DURATION :
-
female 8-21 day(s) after conception lactating female 14 day(s) post-birth
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - behavioral
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
10 mg/kg
-
SEX/DURATION :
-
male 1 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetal death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
400 mg/kg
-
SEX/DURATION :
-
female 9 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
100 mg/kg
-
SEX/DURATION :
-
female 9 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
400 mg/kg
-
SEX/DURATION :
-
female 9 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
500 mg/kg
-
SEX/DURATION :
-
female 9 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
840 mg/kg
-
SEX/DURATION :
-
female 5 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Parenteral
-
DOSE :
-
200 mg/kg
-
SEX/DURATION :
-
female 8 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
1900 mg/kg
-
SEX/DURATION :
-
female 11 day(s) pre-mating female 1-29 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - physical
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
82 mg/kg
-
SEX/DURATION :
-
female 8 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - Central Nervous System
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
206 mg/kg
-
SEX/DURATION :
-
female 8 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
-
TYPE OF TEST :
-
Micronucleus test
-
TYPE OF TEST :
-
Cytogenetic analysis
MUTATION DATA
-
TEST SYSTEM :
-
Rodent - mouse
-
DOSE/DURATION :
-
10 mg/kg
-
REFERENCE :
-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 3,19,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1172 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 198 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1172 No. of Facilities: 201 (estimated) No. of Industries: 2 No. of Occupations: 10 No. of Employees: 17783 (estimated) No. of Female Employees: 15877 (estimated)
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