6211-15-0
6211-15-0结构式
- 常用中文名：吗啡五水硫酸盐
- 常用英文名：morphine sulfate pentahydrate
- CAS号：6211-15-0
- 分子式：C34H50N2O15S
- 分子量：758.83000
- 相关类别： 分析化学 标准品 药典标准品和杂志标准品
- 发布时间：2018-09-09 16:02:01
- 更新时间：2024-01-02 23:12:58
| 中文名 | 吗啡五水硫酸盐 |
|---|---|
| 英文名 | morphine sulfate pentahydrate |
| 中文别名 | 吗啡硫酸盐五水合物 |
| 英文别名 |
levo-morphine sulfate
Kadian (tn) (-)-morphine sulfate Astramor ph (tn) morphin sulfate Morphine sulfate hydrate Depodur (tn) MORPHINESULFATE,USP Depodur morphine sulphate Astramor ph Avinza (tn) Morphia Sulfate Hydrate |
| 沸点 | 476.2ºC at 760 mmHg |
|---|---|
| 熔点 | >240ºC (dec.) |
| 分子式 | C34H50N2O15S |
| 分子量 | 758.83000 |
| 闪点 | 241.8ºC |
| 精确质量 | 758.29300 |
| PSA | 234.99000 |
| LogP | 2.37850 |
| 储存条件 | Controlled Substance, -20°C Freezer |
| 水溶解性 | ethanol: 1.8 mg/mL |
|
Section 1. Chemical Product and Company Identification Morphine sulfate Common Name/ Trade Name Morphine sulfate Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Flammable LimitsNot available. These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...). Products of Combustion Fire Hazards in Presence of Slightly flammable to flammable in presence of open flames and sparks, of heat. Various SubstancesNon-flammable in presence of shocks. Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesSlightly explosive in presence of open flames and sparks. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onAs with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source. Fire Hazards Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust Hazardsexplosion hazard. Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large Spill Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Morphine sulfate Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, alkalis. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Powdered solid.)OdorOdorless. Not available. Taste Molecular Weight758.85 g/mole White. Color Not available. pH (1% soln/water) Boiling PointNot available. 250°C (482°F) Melting Point Critical TemperatureNot available. Specific GravityNot available. Vapor PressureNot applicable. Vapor DensityNot available. Not available. Volatility Odor ThresholdNot available. Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Dispersion PropertiesSee solubility in water. SolubilitySoluble in cold water. Section 10. Stability and Reactivity Data StabilityThe product is stable. Instability TemperatureNot available. Conditions of InstabilityExcessive heat, incompatible materials Incompatibility with various Reactive with oxidizing agents, alkalis. substances Morphine sulfate CorrosivityNon-corrosive in presence of glass. Special Remarks onIncompatible with alkalies, tannic acid, iodic acid, potassium permanganate, borax, chlorates, ferric chloride, Reactivityiodides, lead acetate, magnesia, spirit nitrous ether, mercury bichloride, and gold salts. Sensitive to light. Special Remarks onNot available. Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsAcute oral toxicity (LD50): 973 mg/kg [Rat]. Chronic Effects on Humans May cause damage to the following organs: central nervous system (CNS). Other Toxic Effects onHazardous in case of ingestion, of inhalation. HumansSlightly hazardous in case of skin contact (irritant, permeator). Special Remarks onNot available. Toxicity to Animals Special Remarks onMay cause adverse reproductive effects and birth defects (teratogenic). May affect genetic material (mutagenic) Chronic Effects on HumansHuman: passes through the placenta, excreted in maternal milk. Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause slight irritation. May be absorbed through broken or inflammed skin. Eyes: May cause slight eye irritation. Inhalation: May cause respiratory tract and mucous membrane irritaiton with sneezing and/or coughing. Inhalation of large quantities may cause lung edema, respiratory difficulties, dizziness, and have an anesthetic effect (symptoms similar to ingestion). Ingestion: Narcotic! May Be Habit Forming! It may cause gastrointestinal tract irritaiton (disturbances) with nausea, vomiting, constipation. Ingestion of large amounts may affect behavior/central nervous system (drowsiness, dizziness, slurred speech, somnolence, mental exhilaration, confusion, mood changes, restlessness), metabolism (anorexia), cardiovascular system (heart palpitations, low blood pressure, hypertension, arrhythmias, acute ventricular failrue, bradycardia, cardia arrest). Other symptoms may include dry mouth, sweating, facila flushing, rash, non-responsive contracted pupils, and hypothermia, labored breathing causing cyanosis, flaccid skeletal muscles. Pneumonia, pulmonary edema, shock, coma, and even death may occur in severe cases. Chronic Potential Health Effects: Inhalation: Prolonged or repeated inhalation may cause respiratory irritation, tightness of the chest, asthma, and bronchitis. Ingestion: Prolonged or repeated ingestion may cause habituation or addiction. It may affect the blood, urinary system , and metabolism (anorexia). Skin: May cause contact dermatitis in sensitized indivduals Sensitive individuals may also develop anaphylatic (allergic) reactions upon re-exposure by inhalation or ingestion. Section 12. Ecological Information Not available. Ecotoxicity Not available. BOD5 and COD Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe products of degradation are less toxic than the product itself. of Biodegradation Not available. Special Remarks on the Products of Biodegradation Morphine sulfate Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). Not applicable. Identification Not applicable. Special Provisions for Transport DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms No products were found. Federal and State Regulations California Proposition 65 Warnings Other RegulationsMorphine Sulfate (CAS no. 64-31-3) is on the Canadian Domestic Substances list. Morphine Sulfate Pentahydrate (CAS no. 6211-15-0) is not in the Canadian Domestic Substances list. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)R22- Harmful if swallowed.S2- Keep out of the reach of children. S46- If swallowed, seek medical advice immediately and show this container or label. Health Hazard HMIS (U.S.A.)1 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) Morphine sulfate ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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