60-41-3

• 常用中文名：硫酸士的宁
• 常用英文名：STRYCHNINE
• CAS号：60-41-3
• 分子式：C₄₂H₄₆N₄O₈S
• 分子量：766.90200
• 相关类别： 天然产物 生物碱
• 发布时间：2018-09-30 15:39:24
• 更新时间：2024-01-02 19:29:56
• 下载msds

名称

• 中文名: 士的宁半硫酸盐
• 英文名: strychnine
• 中文别名: 硫酸马钱子碱五水化合物; 马钱子碱硫酸盐; 硫酸士的宁
• 英文别名: Strychnine Sulfate BPC; antivampire; vampirol; Strychniniumsulfat; EINECS 200-319-7; MFCD00005941; STRYCHNINE ALKALOID; L-STRYCHNINE; strychiniumsulfate

物化性质

• 沸点: 559.9ºC at 760 mmHg
• 熔点: 284-286 °C(lit.)
• 分子式: C₄₂H₄₆N₄O₈S
• 分子量: 766.90200
• 闪点: 292.4ºC
• 精确质量: 766.30400
• PSA: 148.54000
• LogP: 4.61880
• 水溶解性: chloroform: clear to hazy
• 计算化学:

  1、 计疏水参数计算参考值（XlogP）：

  2、 氢键供体数量：2

  3、 氢键受体数量：10

  4、 可旋转化学键数量：0

  5、 互变异构体数量：

  6、 拓扑分子极性表面积（TPSA）：140

  7、 重原子数量：55

  8、 表面电荷：0

  9、 复杂度：771

  10、同位素原子数量：0

  11、确定原子立构中心数量：12

  12、不确定原子立构中心数量：0

  13、确定化学键立构中心数量：0

  14、不确定化学键立构中心数量：0

  15、共价键单元数量：3

MSDS

Section 1. Chemical Product and Company Identification Strychnine Hemisulfate Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Chemical Name Chemical Family Strychnine Hemisulfate Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationEvacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical attention. IngestionIf swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product Non-flammable. Auto-Ignition Temperature Not applicable. Flash PointsNot applicable. Flammable LimitsNot applicable. Products of CombustionNot available. Fire Hazards in Presence of Not applicable. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. Fire Fighting MediaNot applicable. and Instructions Special Remarks onNot available. Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Large Spill Poisonous solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to disposal. Strychnine Hemisulfate Section 7. Handling and Storage PrecautionsDo not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as acids, alkalis. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Powdered solid.)OdorNot available. TasteBitter. Molecular Weight383.5 g/mole ColorOff-white. pH (1% soln/water)Not available. Not available. Boiling Point Melting PointNot available. Not available. Critical Temperature Specific GravityNot available. Vapor PressureNot applicable. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Dispersion PropertiesSee solubility in water. SolubilitySoluble in cold water. Section 10. Stability and Reactivity Data The product is stable. Stability Instability TemperatureNot available. Conditions of InstabilityExcess heat, incompatible materials, dust generation Reactive with acids, alkalis. Incompatibility with various substances Not available. Corrosivity Strychnine Hemisulfate Incompatible with alkalies, alkali carbonates, bicarbonates, benzoates, dichromates, bromides, iodides, tannic and Special Remarks on Reactivitypicric acids, salicylates, borax, gold chlorides, piperazine. Not available. Special Remarks on Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsAcute oral toxicity (LD50): 2.6 mg/kg [Rat]. Chronic Effects on Humans Not available. Other Toxic Effects onVery hazardous in case of ingestion, of inhalation. HumansSlightly hazardous in case of skin contact (irritant). Special Remarks onNot available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: Inhalation of dust or fumes (when heated to decompositioni) can result in respiratory tract irritation with chemical pneumonitis, bronchospasm, or noncardiogenic pulmonary edema. It is rapidly absorbed from the respiratory tract, and intranasally resulting in toxicity within 30 minutes. Ingestion: May be fatal if swallowed. It is rapidly absorbed from the gastrointestinal tract. Styrchnine poisoning causes nausea, vomiting, and profuse diarrhea. It can affect the cardiovascular system, respiration, behavior/central nevrous system, blood and brain. It is a central nervous system stimulant which can cause severe headaches, and tonic convulsions. A prodromal syndrome including muscular cramps, stiffness, and agitation is commonly reported prior to the onset of convulsions; generalized convulsions may be the initial event. Generalized convulsions usually occur within 15 to 60 minutes after acute ingestion and within 30 minutes after being absorbe from the respiratory tract. Hypothermia (low body temperature), hypotension (low blood pressure), and hypertension (high blood pressure) have been noted in Strychnine poisoning. Hypotension appears to be due to marked acidosis and hypoxia in individuals with severe poisoning. Severe and prolonged convulsions may result in marked hyperthermia (high body temperature). Temperatures as high as 43 C. have been reported. Bilateral horizontal pendular nystagmus (involuntary eye movement) may occur. Bradycardia (slow heartbeat) can be associated with hypotension and tachycardia (fast heartbeat) as well as tachypena (fast, shallow breathing)commonly accompanies agitation and neuromuscular hyperactivity. The affected individual may complain of chest tightness, difficulty breathing, and a feeling of suffocation. Cardiac arrest may result from severe or prolonged convulsions or respiratory arrest. With severe or prolonged convulsions, sustained contractions of the chest wall muscles and diaphragm may lead to respiratory paralysis. A period of flaccid paralysis with apnea (no breathing) and cyanosis (bluish discoloration) may also occur after the period of convulsions. Renal failure, rapid breakdown of skeletal muscle tissue (Rhabdomyolysis), multiple organ failure (including liver necrosis) may also occur. Death is usually due to respiratory failure. Section 12. Ecological Information Not available. Ecotoxicity BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe products of degradation are less toxic than the product itself. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Strychnine Hemisulfate Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information DOT ClassificationCLASS 6.1: Poisonous material. : Strychnine salt (styrchnine hemisulfate) UNNA: 1692 PG: I Identification Not available. Special Provisions for Transport DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms Illinois toxic substances disclosure to employee act: Strychnine Hemisulfate Federal and State Illinois chemical safety act: Strychnine Hemisulfate Regulations New York release reporting list: Strychnine Hemisulfate Pennsylvania RTK: Strychnine Hemisulfate Massachusetts RTK: Strychnine Hemisulfate Massachusetts spill list: Strychnine Hemisulfate New Jersey: Strychnine Hemisulfate New Jersey spill list: Strychnine Hemisulfate Louisiana RTK reporting list: Strychnine Hemisulfate SARA 302/304/311/312 extremely hazardous substances: Strychnine Hemisulfate CERCLA: Hazardous substances.: Strychnine Hemisulfate: 10 lbs. (4.536 kg) CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found Proposition 65to cause cancer which would require a warning under the statute: No products were found. Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsOSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No. 200-47-7). Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non-Domestic Substances List (NDSL) China: Not listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Not listed on National Inventory (PICCS). Australia: Not listed on AICS. WHMIS (Canada) CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC). Other Classifications DSCL (EEC)R28- Very toxic if swallowed.S28- After contact with skin, wash immediately with plenty of [***] S36/37- Wear suitable protective clothing and gloves. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Strychnine Hemisulfate Health Hazard HMIS (U.S.A.)3 National Fire Protection 0 Flammability 0 Association (U.S.A.) Fire Hazard 3 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Safety glasses. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WL2550000 CAS REGISTRY NUMBER : 60-41-3 LAST UPDATED : 199709 DATA ITEMS CITED : 17 MOLECULAR FORMULA : C21-H22-N2-O2.1/2H2-O4-S MOLECULAR WEIGHT : 383.49 WISWESSER LINE NOTATION : T6 G656 B7 C6 E5 D 5ABCEF A& FX MNV QO VN SU AHT&&TTTTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 37 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Cardiac - pulse rate Lungs, Thorax, or Respiration - pleural thickening REFERENCE : JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 10,120,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 31,113,1942 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1125,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1700 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 570 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 144,416,1963 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 14,111,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IVEBBN International Journal for Vitamin and Nutrition Research, Supplement. (Verlag Hans Huber, Laenggastr. 76, CH-3000 Bern 9, Switzerland) No.12- 1972- Volume(issue)/page/year: 16,31,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1250 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,153,1939 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 475 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,127,1943 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 2500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 35,316,1936 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 10900 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 144,416,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 4800 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 144,416,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 390 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 144,416,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 5600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84661 No. of Facilities: 872 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3575 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84661 No. of Facilities: 229 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1241 (estimated) No. of Female Employees: 690 (estimated)

安全

• 符号: GHS06, GHS09
• 信号词: Danger
• 危害声明: H300-H330-H410
• 警示性声明: P260-P264-P273-P284-P301 + P310-P310
• 危害码 (欧洲): T+,N
• 风险声明 (欧洲): 27/28-50/53-26/28
• 安全声明 (欧洲): S36/37-S45-S60-S61-S28-S13
• 危险品运输编码: UN 1692 6.1/PG 1
• WGK德国: 3
• RTECS号: WL2550000
• 包装等级: I
• 危险类别: 6.1(a)