66-32-0

• 常用中文名：硝酸士的宁
• 常用英文名：STRYCHNINE NITRATE
• CAS号：66-32-0
• 分子式：C₂₁H₂₃N₃O₅
• 分子量：397.42400
• 相关类别： 原料药 神经系统用药 中枢兴奋药
• 发布时间：2018-06-14 23:12:09
• 更新时间：2024-01-02 10:54:54

• 生化研究。

名称

• 中文名: 硝酸士的宁
• 英文名: strychnine nitrate
• 中文别名: 士的宁硝酸盐
• 英文别名: strychnidin-10-one,nitrate; StrychnineHCL,(L-A046); Strychnin-Nitrat; strychnine,mononitrate; Strychninenitrate,(L-A044); strychnidin-10-one,mononitrate; (-)-strychnine nitrate; EINECS 200-627-1; (-)-strychninium nitrate; MFCD00078519

物化性质

• 沸点: 634.3ºC at 760 mmHg
• 分子式: C₂₁H₂₃N₃O₅
• 分子量: 397.42400
• 闪点: 337.4ºC
• 精确质量: 397.16400
• PSA: 98.83000
• LogP: 2.27090
• 储存条件:

  本品应密封于阴凉避光处保存。

• 计算化学:

  1、 氢键供体数量：1

  2、 氢键受体数量：5

  3、 可旋转化学键数量：0

  4、 拓扑分子极性表面积（TPSA）：100

  5、 重原子数量：29

  6、 表面电荷：0

  7、 复杂度：708

  8、 同位素原子数量：0

  9、 确定原子立构中心数量：4

  10、 不确定原子立构中心数量：2

  11、 确定化学键立构中心数量：0

  12、 不确定化学键立构中心数量：0

  13、 共价键单元数量：2

• 更多:

  1. 性状：无色针状结晶或白色结晶性粉末。无气味。

  2. 密度（g/mL,25/4℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：1g产品溶于42ml冷水、10ml沸水、150ml乙醇、80ml60℃的乙醇、105ml氯仿、50ml甘油，不溶于乙醚。pH约为5.7。剧毒！

MSDS

Section I.Chemical Product and Company Identification Chemical Name Strychnine Nitrate Portland OR SynonymStrychnine nitrate salt Chemical FormulaC21H22N2O2•HNO3 66-32-0 CAS Number Section II.Composition and Information on Ingredients Toxicology Data Chemical NameCAS Number Percent (%)TLV/PEL Strychnine Nitrate66-32-0Min. 99.0 (T) Not available.Rat LD50 (oral) 16mg/kg Mouse LD50 (oral) 0.93mg/kg Rabbit LD50 (intravenous) 0.25mg/kg Section III. Hazards Identification Highly toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or Acute Health Effects death. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound. CARCINOGENIC EFFECTS : Not available. Chronic Health Effects MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : Not available. Toxicity to the reproductive system: Not available. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many human organs. Section IV.First Aid Measures Eye ContactCheck for and remove any contact lenses. DO NOT use an eye ointment. Flush eyes with running water for a minimum of 15 minutes, occasionally lifting the upper and lower eyelids. Seek medical attention. Skin ContactIf the chemical gets spilled on a clothed portion of the body, remove the contaminated clothes as quickly as possible, protecting your own hands and body. Place the victim under a deluge shower. If the chemical touches the victim's exposed skin, such as the hands: Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash any contaminated clothing before reusing. InhalationIf the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not improve. IngestionINDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. SEEK IMMEDIATE MEDICAL ATTENTION in case of ingestion of a radioactive material. Section V.Fire and Explosion Data Not available. FlammabilityNot available.Auto-Ignition Not available. Flash PointsNot available.Flammable Limits Combustion ProductsThese products include toxic carbon oxides (CO,CO2), nitrogen oxides (NO, NO2). Fire Hazards No specific information is available regarding the flammability of this compound in the presence of various materials. Explosion HazardsRisks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. No additional information is available regarding the risks of explosion. Fire Fighting MediaSMALL FIRE: Use DRY chemicals, CO2, water spray or foam. LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet. and Instructions Consult with local fire authorities before attempting large scale fire-fighting operations. Continued on Next Page Strychnine Nitrate Section VI.Accidental Release Measures Spill CleanupHighly toxic material. Stop leak if without risk. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce Instructions assistance on disposal. Section VII. Handling and Storage HIGHLY TOXIC COMPOUND. Keep locked up. LIGHT SENSITIVE--store in a darkened cabinet or closet. Keep away from Handling and Storage heat and sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all Information equipment containing material. DO NOT ingest. DO NOT breathe dust. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Always store away from incompatible compounds such as oxidizing agents, alkalis, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric acids, salicyclates, borax, gold chlorides, and piperazine. Section VIII. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Splash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator should be used to avoid Personal Protection inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Not available. Exposure Limits Section IX. Physical and Chemical Properties Physical state @ 20°CSolid. (Powder.)Solubility Soluble in water, ethanol, chloroform, glycerol. Not available.Insoluble in ether. Specific Gravity Molecular Weight397.43Partition CoefficientNot available. Boiling PointNot available.Vapor PressureNot available. Not available.Not available. Melting PointVapor Density Refractive IndexNot available.VolatilityNot available. Not available.Odorless. Critical TemperatureOdor Not available.Not available. ViscosityTaste Section X.Stability and Reactivity Data This material is stable if stored under proper conditions. (See Section VII for instructions) Stability Conditions of InstabilityLIGHT SENSITIVE. Incompatibilities Highly reactive with oxidizing agents, alkalis, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric acids, salicyclates, borax, gold chlorides, and piperazine. . Section XI. Toxicological Information WL2450000 RTECS Number Ingestion. Inhalation. Eye contact. Skin contact. Routes of Exposure Rat LD50 (oral) 16mg/kg Toxicity Data Mouse LD50 (oral) 0.93mg/kg Rabbit LD50 (intravenous) 0.25mg/kg CARCINOGENIC EFFECTS : Not available. Chronic Toxic Effects MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : Not available. Toxicity to the reproductive system: Not available. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many human organs. Highly toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or Acute Toxic Effects death. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound. Continued on Next Page Strychnine Nitrate Section XII.Ecological Information EcotoxicityNot available. Not available. Environmental Fate Section XIII. Disposal Considerations Recycle to process, if possible. Consult your local or regional authorities. You may be able to dissolve or mix material with a Waste Disposal combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state, and local regulations when disposing of this substance. Section XIV. Transport Information DOT ClassificationDOT CLASS 6.1: Poisonous material. PIN Number Proper Shipping NameStrychnine salts. I Packing Group (PG) DOT Pictograms Section XV. Other Regulatory Information and Pictograms TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40 CFR 720.36 (C) for those products not on the inventory list: (EPA) (i) These products are supplied solely for use in research and development by or under the supervision of a technically qualified individual as defined in 40 CFR 720.0 et sec. (ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be supplied on an MSDS sheet. WHMIS ClassificationWHMIS CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC). (Canada) EINECS Number (EEC) 200-627-1 EEC Risk StatementsR26/27/28- Very toxic by inhalation, in contact with skin and if swallowed. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 急性毒性：人口经LDLo：500 ug/kg；大鼠口经LD50：16200 ug/kg；大鼠皮下注射LDLo：3 mg/kg；大鼠静脉LDLo：600 ug/kg； 小鼠口经LD50：930 ug/kg；小鼠皮下注射LDLo：2 mg/kg；小鼠静脉LDLo：600 ug/kg； CHEMICAL IDENTIFICATION RTECS NUMBER : WL2450000 CHEMICAL NAME : Strychnine, mononitrate CAS REGISTRY NUMBER : 66-32-0 LAST UPDATED : 199709 DATA ITEMS CITED : 14 MOLECULAR FORMULA : C21-H22-N2-O2.H-N-O3 MOLECULAR WEIGHT : 397.47 WISWESSER LINE NOTATION : T6 G656 B7 C6 E5 D 5ABCEF A& FX MNV QO VN SU AHT&&TTTTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,329,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 16200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,377,1982 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - tetany REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 187,607,1937 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 600 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1778,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 930 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 22,425,1984 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,458,1967 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 600 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1778,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 207,688,1949 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,329,1977 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,329,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 250 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 21,1,1958 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - pig DOSE/DURATION : 20 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,329,1977 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 131,171,1928 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraarterial SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 131,171,1928

安全

• 危害码 (欧洲): T+: Very toxic;
• 风险声明 (欧洲): R26/27/28
• 安全声明 (欧洲): S22-S36/37/39-S45
• 危险品运输编码: UN 1692 6.1/PG 1
• WGK德国: 3
• RTECS号: WL2450000
• 包装等级: I
• 危险类别: 6.1(a)