60-41-3
60-41-3 structure
- Name: STRYCHNINE
- Chemical Name: strychnine
- CAS Number: 60-41-3
- Molecular Formula: C42H46N4O8S
- Molecular Weight: 766.90200
- Catalog: Natural product Alkaloid
- Create Date: 2018-09-30 15:39:24
- Modify Date: 2024-01-02 19:29:56
| Name | strychnine |
|---|---|
| Synonyms |
Strychnine Sulfate BPC
antivampire vampirol Strychniniumsulfat EINECS 200-319-7 MFCD00005941 STRYCHNINE ALKALOID L-STRYCHNINE strychiniumsulfate |
| Boiling Point | 559.9ºC at 760 mmHg |
|---|---|
| Melting Point | 284-286 °C(lit.) |
| Molecular Formula | C42H46N4O8S |
| Molecular Weight | 766.90200 |
| Flash Point | 292.4ºC |
| Exact Mass | 766.30400 |
| PSA | 148.54000 |
| LogP | 4.61880 |
| Water Solubility | chloroform: clear to hazy |
|
Section 1. Chemical Product and Company Identification Strychnine Hemisulfate Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym
Chemical Name Chemical Family Strychnine Hemisulfate Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationEvacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical attention. IngestionIf swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product Non-flammable. Auto-Ignition Temperature Not applicable. Flash PointsNot applicable. Flammable LimitsNot applicable. Products of CombustionNot available. Fire Hazards in Presence of Not applicable. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. Fire Fighting MediaNot applicable. and Instructions Special Remarks onNot available. Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Large Spill Poisonous solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to disposal. Strychnine Hemisulfate Section 7. Handling and Storage PrecautionsDo not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as acids, alkalis. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Powdered solid.)OdorNot available. TasteBitter. Molecular Weight383.5 g/mole ColorOff-white. pH (1% soln/water)Not available. Not available. Boiling Point Melting PointNot available. Not available. Critical Temperature Specific GravityNot available. Vapor PressureNot applicable. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Dispersion PropertiesSee solubility in water. SolubilitySoluble in cold water. Section 10. Stability and Reactivity Data The product is stable. Stability Instability TemperatureNot available. Conditions of InstabilityExcess heat, incompatible materials, dust generation Reactive with acids, alkalis. Incompatibility with various substances Not available. Corrosivity Strychnine Hemisulfate Incompatible with alkalies, alkali carbonates, bicarbonates, benzoates, dichromates, bromides, iodides, tannic and Special Remarks on Reactivitypicric acids, salicylates, borax, gold chlorides, piperazine. Not available. Special Remarks on Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsAcute oral toxicity (LD50): 2.6 mg/kg [Rat]. Chronic Effects on Humans Not available. Other Toxic Effects onVery hazardous in case of ingestion, of inhalation. HumansSlightly hazardous in case of skin contact (irritant). Special Remarks onNot available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: Inhalation of dust or fumes (when heated to decompositioni) can result in respiratory tract irritation with chemical pneumonitis, bronchospasm, or noncardiogenic pulmonary edema. It is rapidly absorbed from the respiratory tract, and intranasally resulting in toxicity within 30 minutes. Ingestion: May be fatal if swallowed. It is rapidly absorbed from the gastrointestinal tract. Styrchnine poisoning causes nausea, vomiting, and profuse diarrhea. It can affect the cardiovascular system, respiration, behavior/central nevrous system, blood and brain. It is a central nervous system stimulant which can cause severe headaches, and tonic convulsions. A prodromal syndrome including muscular cramps, stiffness, and agitation is commonly reported prior to the onset of convulsions; generalized convulsions may be the initial event. Generalized convulsions usually occur within 15 to 60 minutes after acute ingestion and within 30 minutes after being absorbe from the respiratory tract. Hypothermia (low body temperature), hypotension (low blood pressure), and hypertension (high blood pressure) have been noted in Strychnine poisoning. Hypotension appears to be due to marked acidosis and hypoxia in individuals with severe poisoning. Severe and prolonged convulsions may result in marked hyperthermia (high body temperature). Temperatures as high as 43 C. have been reported. Bilateral horizontal pendular nystagmus (involuntary eye movement) may occur. Bradycardia (slow heartbeat) can be associated with hypotension and tachycardia (fast heartbeat) as well as tachypena (fast, shallow breathing)commonly accompanies agitation and neuromuscular hyperactivity. The affected individual may complain of chest tightness, difficulty breathing, and a feeling of suffocation. Cardiac arrest may result from severe or prolonged convulsions or respiratory arrest. With severe or prolonged convulsions, sustained contractions of the chest wall muscles and diaphragm may lead to respiratory paralysis. A period of flaccid paralysis with apnea (no breathing) and cyanosis (bluish discoloration) may also occur after the period of convulsions. Renal failure, rapid breakdown of skeletal muscle tissue (Rhabdomyolysis), multiple organ failure (including liver necrosis) may also occur. Death is usually due to respiratory failure. Section 12. Ecological Information Not available. Ecotoxicity BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe products of degradation are less toxic than the product itself. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Strychnine Hemisulfate Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information DOT ClassificationCLASS 6.1: Poisonous material. : Strychnine salt (styrchnine hemisulfate) UNNA: 1692 PG: I Identification Not available. Special Provisions for Transport DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms Illinois toxic substances disclosure to employee act: Strychnine Hemisulfate Federal and State Illinois chemical safety act: Strychnine Hemisulfate Regulations New York release reporting list: Strychnine Hemisulfate Pennsylvania RTK: Strychnine Hemisulfate Massachusetts RTK: Strychnine Hemisulfate Massachusetts spill list: Strychnine Hemisulfate New Jersey: Strychnine Hemisulfate New Jersey spill list: Strychnine Hemisulfate Louisiana RTK reporting list: Strychnine Hemisulfate SARA 302/304/311/312 extremely hazardous substances: Strychnine Hemisulfate CERCLA: Hazardous substances.: Strychnine Hemisulfate: 10 lbs. (4.536 kg) CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found Proposition 65to cause cancer which would require a warning under the statute: No products were found. Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsOSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No. 200-47-7). Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non-Domestic Substances List (NDSL) China: Not listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Not listed on National Inventory (PICCS). Australia: Not listed on AICS. WHMIS (Canada) CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC). Other Classifications DSCL (EEC)R28- Very toxic if swallowed.S28- After contact with skin, wash immediately with plenty of [***] S36/37- Wear suitable protective clothing and gloves. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Strychnine Hemisulfate Health Hazard HMIS (U.S.A.)3 National Fire Protection 0 Flammability 0 Association (U.S.A.) Fire Hazard 3 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Safety glasses. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H330-H410 |
| Precautionary Statements | P260-P264-P273-P284-P301 + P310-P310 |
| Hazard Codes | T+,N |
| Risk Phrases | 27/28-50/53-26/28 |
| Safety Phrases | S36/37-S45-S60-S61-S28-S13 |
| RIDADR | UN 1692 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | WL2550000 |
| Packaging Group | I |
| Hazard Class | 6.1(a) |