33252-64-1

• 常用中文名：2-羟基-3-硝基-5-(三氟甲基)吡啶
• 常用英文名：3-Nitro-5-(trifluoromethyl)-2-pyridinol
• CAS号：33252-64-1
• 分子式：C₆H₃F₃N₂O₃
• 分子量：208.095
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 羟基吡啶
• 发布时间：2018-12-25 13:12:57
• 更新时间：2024-01-02 16:20:00

名称

• 中文名: 2-羟基-3-硝基-5-三氟甲基吡啶
• 英文名: 3-Nitro-5-(trifluoromethyl)pyridin-2-ol
• 中文别名: 2-羟基-3-硝基-5-(三氟甲基)吡啶; 3-硝基-5-(三氟甲基)吡啶-2-醇
• 英文别名: 3-nitro-5-(trifluoromethyl)pyridin-2(1H)-one; 3-nitro-5-(trifluoromethyl)-1H-pyridin-2-one; MFCD00276983; 3-Nitro-5-(trifluoromethyl)-2-pyridinol; 2(1H)-pyridinone, 3-nitro-5-(trifluoromethyl)-; 3-Nitro-5-(trifluoromethyl)pyridin-2-ol

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 276.2±40.0 °C at 760 mmHg
• 熔点: 183-186ºC
• 分子式: C₆H₃F₃N₂O₃
• 分子量: 208.095
• 闪点: 120.9±27.3 °C
• 精确质量: 208.009583
• PSA: 78.94000
• LogP: -0.54
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.490
• 储存条件: Room temperature.

MSDS

Name: 3-Nitro-5-(trifluoromethyl)pyridin-2-ol 97% Material Safety Data Sheet Synonym: 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridin CAS: 33252-64-1 Section 1 - Chemical Product MSDS Name:3-Nitro-5-(trifluoromethyl)pyridin-2-ol 97% Material Safety Data Sheet Synonym:2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridin Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 33252-64-1 3-Nitro-5-(trifluoromethyl)pyridin-2-o 97% unlisted Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 33252-64-1: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: pale yellow Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 183 - 186 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C6H3F3N2O3 Molecular Weight: 208 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Oxidizing agents, reducing agents, bases. Hazardous Decomposition Products: Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide, fluorine, hydrogen fluoride gas. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 33252-64-1 unlisted. LD50/LC50: Not available. Carcinogenicity: 3-Nitro-5-(trifluoromethyl)pyridin-2-ol - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 33252-64-1: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 33252-64-1 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 33252-64-1 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi:Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S37/39
• 海关编码: 2933399090

合成路线

33252-63-0 ~59% 33252-64-1

文献：Respiratorius AB Patent: WO2009/7418 A1, 2009 ; Location in patent: Page/Page column 23 ;

53359-69-6 ~74% 33252-64-1

文献：Sapegin, Alexander V.; Kalinin, Stanislav A.; Smirnov, Alexey V.; Dorogov, Mikhail V.; Krasavin, Mikhail Tetrahedron, 2014 , vol. 70, # 5 p. 1077 - 1083

74784-70-6 ~% 33252-64-1

文献：Tetrahedron, , vol. 70, # 5 p. 1077 - 1083

上下游产品

上游产品  3
33252-63-0 53359-69-6 74784-70-6
下游产品  10
288246-61-7 90778-25-9 72587-15-6 1214336-90-9
1214370-77-0 866775-16-8 866775-17-9 866775-18-0
89571-66-4 89571-67-5

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%